Monoclonal antibodies to antigens expressed by hematopoietic fac

Details Monoclonal antibodies to antigens expressed by hematopoietic fac Monoclonal antibodies to antigens expressed by hematopoietic fac

1997-08-18

2000-01-11

Chan, Christina Y.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Animal cell, per se, expressing immunoglobulin, antibody, or...

435 7021, 435452, 435325, 435326, 435332, 435343, 5303871, 5303881, 5303882, 5303887, 53038873, C12N 512, C12N 520, C07K 1628

Patent

active

060135190

ABSTRACT:
The present invention relates to monoclonal antibodies (MAb) to hematopoietic facilitatory cells (FC). In particular, it relates to MAb against antigens expressed by murine FC, methods of generating the antibodies, and methods of using the same. MAb directed to markers that are expressed specifically or at higher levels by FC than by most other bone marrow cells have a wide range of applications, including but not limited to, rapid isolation of FC, identification of FC in a donor cell preparation, and molecular cloning of the genes encoding the corresponding target antigens.

REFERENCES:
Idstad et al. Transplantation 41:372-376 (1986).
Sykes et al. J. Immunol. 143: 3503-3511(1989).
Kaufman et al. Blood 82(10 suppl 1):456A (1993).
Kaufman et al. J. Immunol. 150(8 Part 2): 321A (1993).
ATCC Catalog of Cellines and Hybridomis, 7th ED 1992 p. 434.
Daul Fundamental Immunol. Raven Press NY 1993 p. 242 Only.

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