Monoclonal antibodies to an autocrine growth factor antigen that

Details Monoclonal antibodies to an autocrine growth factor antigen that Monoclonal antibodies to an autocrine growth factor antigen that

1990-01-10

1994-07-19

Saunders, David

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 724, 435 78, 436503, 436518, 436536, 436813, 540399, 530403, 530828, C07K 1500, G01N 33574

Patent

active

053308964

ABSTRACT:
A monoclonal antibody recognizing an autocrine growth factor that reacts with activated lymphocytes and cancer cells is described. The growth factor, a small glycoprotein is distinct from interleukin 2 and other known growth factors by function, structure and tissue distribution. A homologous growth factor is present in lymphoid tissues of a wide range of vertebrate species. Diagnostic and therapeutic uses of the growth factor and antibody-growth factor complex are disclosed. Also disclosed are therapeutic uses of synthetic analogues and peptide derivatives of the antigen.

REFERENCES:
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patent: 4832940 (1989-05-01), Ege
patent: 5017691 (1991-05-01), Lee et al.
L. Rimsky et al., Jour. Immunol., 136, 3304-3310, 1986.
T. Kupper et al., Chem. Abst. 107 (13), 114014r, 1987.
Wakasugi et al., Proc. Natl. Acad. Sci. USA, 87, 8282-8286, 1990.

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