Monoclonal antibodies to a pan-malarial antigen

Details Monoclonal antibodies to a pan-malarial antigen Monoclonal antibodies to a pan-malarial antigen

1986-12-08

1991-03-19

Draper, Garnette D.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

530388, 530808, 530809, 435 7021, 4351722, 43524026, 43524027, 424 858, 436547, 436548, 935 89, 935 95, 935106, 935107, 935108, C07K 1500, C12N 500

Patent

active

050012258

ABSTRACT:
A continuous hybridoma cell line, designated 7H8, which secretes a monoclonal antibody (MAb 7H8) of the IgM class and which binds to a protein present in species of the genus Plasmodium. MAb 7H8 also recognizes an antigen (antigen Pf93) unique to P. falciparum. Methods of isolating the substantially pure antigen using the antibody of the present invention are disclosed. MAb 7H8 is well suited for use in immunometric assays. Preferred is a two-sited assay developed with MAb 7H8. Anti-idiotypic and anti anti-idiotypic antibodies to MAb 7H8 are disclosed. The antibodies and antigens of the present invention are useful for immunodiagnostic and immunotherapeutic treatment of malarial diseases of man and animals.

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