Monoclonal antibodies to a new antigenic marker in epithelial pr

Details Monoclonal antibodies to a new antigenic marker in epithelial pr Monoclonal antibodies to a new antigenic marker in epithelial pr

1988-06-03

1992-11-10

Doll, John

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

43524027, 435 7021, 435 723, 5303888, C07K 1528, C12N 520, C12P 2108

Patent

active

051625040

ABSTRACT:
Monoclonal antibodies to prostatic cells, are produced by a hybridoma formed by fusing mouse lymphocytes and mouse myeloma cells. The monoclonal antibodies show specificity for a non-soluble, membrane associated, organ specific antigenic determinant limited in its distribution to normal and neoplastic, human prostate epithelial cells. The monoclonal antibodies, specifically 7E11-C5 monoclonal antibodies, may be suitable for diagnostic uses.

REFERENCES:
Wright et al., Cancer Res. 43:5509-16, 1983.
Horoszewicz et al., Anticancer Res. 7:927-36, 1987.
Frankel et al., PNAS 79:903-907, 1982.
Webb et al., Cancer Immunol Immunother 17:7-17, 1984.
Finstad et al., PNAS 82:2955-59, 1985.
Campbell "Monoclonal Antibody Technology" Elsevier Publ. 1984, 265 pages.

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