Monoclonal antibodies to a broad range of mammalian terminal deo

Details Monoclonal antibodies to a broad range of mammalian terminal deo Monoclonal antibodies to a broad range of mammalian terminal deo

1985-11-26

1989-06-13

Nucker, Christine M.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

530387808, 530809, 4351722, 435 68, C12N 500

Patent

active

048392898

ABSTRACT:
Murine monoclonal antibodies specific to unique antigenic determinants on mammalian terminal deoxynucleotidyl transferases (TdT). The monoclonal antibodies specifically bind to TdT in a wide variety of mammalian cells including human, mouse, rat, rabbit and bovine origin. The monoclonal antibodies are secreted by hybridoma cells derived from fusion of murine plasmacytoma cells with splenocytes from mice immunized with TdT from bovine thymus cells. The monoclonal antibodies can detect small numbers of TdT-positive cells for monitoring of TdT-positive leukemias and lymphomas in multiple species, including human.

REFERENCES:
Augl, et al, Fed. Proc. 42: 2147, 1983.
Bollum, F. J. et al, J. Bio. Chem 259: 5848, 1984.
Sasaki, R. et al, Igaku no Ayum vol. 134(4), 1985, pp. 185-186.
Fuller, S. A. et al, Biochem J. (1985) 231, 105-113.

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