Monoclonal antibodies to a broad range of mammalian terminal deo

Details Monoclonal antibodies to a broad range of mammalian terminal deo Monoclonal antibodies to a broad range of mammalian terminal deo

1989-06-12

1990-12-11

Nucker, Christine

Chemistry: molecular biology and microbiology

Spore forming or isolating process

4351722, 530387, 530808, 530809, 935104, 935110, C12N 500, C12N 1500

Patent

active

049770861

ABSTRACT:
Murine monoclonal antibodies specific to unique antigenic determinants on mammalian terminal deoxynucleotidyl transferases (TdT). The monoclonal antibodies specifically bind to TdT in a wide variety of mammalian cells including human, mouse, rat, rabbit and bovine origin. The monoclonal antibodies are secreted by hybridoma cell lines derived from fusion of murine plasmacytoma cells with splenocytes from mice immunized with TdT from bovine thymus cells. The monoclonal antibodies can detect small numbers of TdT-positive cells from monitoring of TdT-positive leukemias and lymphomas in multple species, including human.

REFERENCES:
Augl et al., Fed. Proc. 42: 2147, 1983.
Bollum, F. J. et al., J. Bio. Chem. 259: 5848, 1984.
Sasaki, R. et al., Igaku no Ayum, vol. 134(4), 1985, pp. 185-186.
Fuller, S. A. et al., Biochem. J. (1985), 231, 105-113.

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