Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Binds bacterium or component thereof or substance produced...
Reexamination Certificate
2011-05-03
2011-05-03
Nickol, Gary B. (Department: 1645)
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Binds bacterium or component thereof or substance produced...
C530S387100, C530S388100
Reexamination Certificate
active
07935345
ABSTRACT:
The invention features compositions relating to antibodies that specifically bind to the protective antigen ofBacillus anthracis, fragments thereof, and nucleic acids encoding same. The invention further features methods of using such compositions.
REFERENCES:
patent: 5591631 (1997-01-01), Leppla et al.
patent: 5677274 (1997-10-01), Leppla et al.
patent: 6828110 (2004-12-01), Lee
patent: 6916474 (2005-07-01), Harvey
patent: 2002/0082386 (2002-06-01), Mangold
patent: 2004/0018193 (2004-01-01), Alibek
patent: 2004/0076638 (2004-04-01), Shiloach
patent: 2004/0166120 (2004-08-01), Thomas
patent: 2004/0171121 (2004-09-01), Leppla
patent: 2004/0235075 (2004-11-01), Cullum
patent: 2005/0031625 (2005-02-01), Mohamed
patent: 2005/0123476 (2005-06-01), Bugge
patent: 2005/0267294 (2005-12-01), Harvey
patent: 2005/0287149 (2005-12-01), Keler
patent: 2006/0083746 (2006-04-01), Young
patent: 2006/0121045 (2006-06-01), Iverson
patent: 2006/0140931 (2006-06-01), Mohamed
patent: 2006/0153839 (2006-07-01), Mohamed
Little, Passive protection by polyclonal antibodies againstBacillus anthracisinfection in guinea pigs. Infect Immum. Dec. 1997; 65 (12):5171-5.
Welkos, The role of antibodies to Bacillus anthracis and anthrax toxin components in inhibiting the early stages of infection by anthrax spores, Microbiology. Jun. 2001; 147 (Pt 6): 1677-85.
Welkos, In-vitro characterisation of the phagocytosis and fate of anthrax spores in macrophages and the effects of anti-PA antibody, J. Med Microbiol. Oct. 2002; 51 (10):821-31.
Sastry, Generation and characterization of monoclonal antibodies to protective antigen of Bacillus anthracis, Indian J Exp Biol. Feb. 2003; 41 (2):123-8.
Zhao, Neutralizing monoclonal antibody against anthrax lethal factor inhibits intoxication in a mouse model, Hum Antibodies, 2003; 12(4):129-35.
Wild, Human antibodies from immunized donors are protective against anthrax toxin in vivo, Nat Biotechnol. Nov. 2003; 21 (11):1305-6. Epub Oct. 12, 2003.
Karginov, Treatment of anthrax infection with combination of ciprofloxacin and antibodies to protective antigen ofBacillus anthracis, FEMS Immunol Med Microbiol. Jan. 15, 2004;40 (1):71-4.
Wu, Vaccines and immunotherapies for the prevention of infectious diseases having cutaneous manifestations, J Am Acad Dermatol. Apr. 2004;50 (4):495-528; quiz 529-32.
Sawada-Hirai R, Human anti-anthrax protective antigen neutralizing monoclonal antibodies derived from donors vaccinated with anthrax vaccine adsorbed, J Immune Based Ther Vaccines. May 12, 2004;2(1):5.
Mohamed, Enhancement of anthrax lethal toxin cytotoxicity: a subset of monoclonal antibodies against protective antigen increases lethal toxin-mediated killing of murine macrophages, Infect Immun. Jun. 2004;72(6):3276-83.
Zhou, Somatic Hypermutation and diverse immunoglobulin gene usage in the human antibody response to the capsular polysaccharide of streptococcus pneumoniae type 6b, Infect Immun. Jun. 2004:72(6):3505-3514.
Brossier, Functional analysis of Bacillus anthracis protective antigen by using neutralizing monoclonal antibodies, Infect Immun. Nov. 2004;72(11):6313-7.
Huber, Generation of mouse polyclonal and human monoclonal antibodies againstBacillus anthracistoxin, Drugs Exp Clin Res. 2005;31(2):35-43.
Cui, Late treatment with a protective antigen-directed monoclonal antibody improves hemodynamic function and survival in a lethal toxin-infused rat model of anthrax sepsis, J Infect Dis. Feb. 1, 2005;191(3):422-34. Epub Dec. 22, 2004.
Mohamed, A high-affinity monoclonal antibody to anthrax protective antigen passively protects rabbits before and after aerosolizedBacillus anthracisspore challenge, Infect Immun. Feb. 2005;73(2):795-802.
Kasuya, Passive immunotherapy for anthrax toxin mediated by an adenovirus expressing an anti-protective antigen single-chain antibody, Mol Ther. Feb. 2005;11(2):237-44.
Cote, The Detection of Protection Antigen (PA) Associated with spores ofBacillus anthracisand the effects of anti-PA antibodies on spore germination and macrophage interactions, Microb Pathog. May-Jun. 2005;38(5-6):209-25. Epub Apr. 22, 2005.
Xu, Toxin-neutralizing monoclonal antibodies to the different domains of anthrax protective antigen, WEI SHENG WU XUE BAO. Dec. 2005;45(6):947-51.
Peterson, Human monoclonal anti-protective antigen antibody completely protects rabbits and is synergistic with ciprofloxacin in protecting mice and guinea pigs against inhalation anthrax, Infect Immun. Feb. 2006;74(2):1016-24.
Chen, Efficient neutralization of anthrax toxin by chimpanzee monoclonal antibodies against protective antigen, J Infect Dis. Mar. 1, 2006;193(5):625-33. Epub Feb. 2, 2006.
Rivera, A monoclonal antibody toBacillus anthracisprotective antigen defines a neutralizing epitope in domain 1, Infect Immun. Jul. 2006;74(7):4149-56.
Vitale, Prophylaxis and therapy of inhalational anthrax by a novel monoclonal antibody to protective antigen that mimics vaccine-induced immunity, Infect Immun. Oct. 2006;74(10):5840-7.
Lininger, The impact of incomplete vaccination schedules on the magnitude and duration of protective antigen-specific IgG responses in recipients of the US licensed anthrax vaccine, Vaccine. Nov. 13, 2006.
Duc, Immunization against anthrax usingBacillus subtilisspores expressing the anthrax protective antigen, Vaccine. Jan. 4, 2007;25(2):346-55. Epub Aug. 4, 2006.
Sun, Insertion of anthrax protective antigen into liposomal membranes:Effects of a receptor, JBC Papers in Press, Pub. Nov. 14, 2006, The American Society for Biochem and Molecular Bio, Printed Jan. 7, 2007.
Masri, Cloning and expression inE coliof a functional Fab fragment obtained from single human lymphocyte against anthrax toxin, Mol Immunol. Mar. 2007;44(8):2111-6. Epub Oct. 12, 2006.
Reason Donald
Zhou Jianhui
Bozicevic Field & Francis LLP
Chandra Shweta
Children's Hospital & Research Center at Oakland
Francis Carol L.
Nickol Gary B.
LandOfFree
Monoclonal antibodies that specifically bind to and... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Monoclonal antibodies that specifically bind to and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Monoclonal antibodies that specifically bind to and... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2690206