Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1992-12-22
1997-07-01
Scheiner, Toni R.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
53038873, 53038885, 4351722, 435334, 4353431, 4353441, 436548, C07K 1628
Patent
active
056440332
ABSTRACT:
Three monoclonal antibodies defining extracellular epitopes of a unique heterodimeric glycoprotein complex consisting of the human mb-1 protein and the human B29 protein which react with one or more leukemia lymphoma cell specimens selected from the group consisting of B prolymphocytic leukemia cells, B non-Hodgkin's lymphoma cells, B chronic lymphocytic leukemia cells, B hairy cell leukemia cells, and B acute lymphoblastic leukemia cells. The three monoclonal antibodies also react with human non-malignant B cells. The invention also provides a method for producing the new monoclonal antibodies and for diagnostic procedures using the monoclonal antibodies and for the treatment of leukemia-lymphoma patients and patients with immunological diseases. The invention also relates to the isolation and chemical identification of the human B29 and mb-1 proteins of B cell antigen receptor complex. The amino-terminal amino acid sequences of the mb-1 and B29 gene products were determined.
REFERENCES:
Venkitaraman et al., Nature, vol. 352, pp. 777-781 (Aug. 1991).
Seaver, Genetic Engineering News, pp. 10 and 21, (1994).
Kohler et al., Nature, vol. 256, pp. 495-497 (1975).
Kohler et al., Eur. J. Immunol. vol. 6, pp. 511-519 (1976).
Gaifre et al., Methods in Enzymology, vol. 73, pp. 3-47, (1975).
Goding, Journal of Immunological Methods, vol. 39, pp. 285-308 (1980).
Galton et al. "Prolymphocytic leukemia", British J. Haematol, 27: 7, 1974.
Catovsky "Prolymphocytic and hairy cell leukemias", in Henderson ES, Lister TA (eds): Leukemia, Philadelphia, PA, Saunders, 1990, p. 639.
Bearman et al. "Prolymphocytic leukemia: Clinical, histopathological, and cytochemical observations", Cancer 42: 2360, 1978.
Katayama et al. "B-lineage prolymphocytic leukemia as a distinct clinicopathologic entity", Am. J. Pathol. 99: 399, 1980.
Melo et al. "The relationship between chronic lymphocytic leukaemia and prolymphocytic leukaemia: I. Clinical and laboratory features of 300 patients and characterization of an intermediate group", British J. Haematol, 63: 377, 1986.
Foon et al. "Immunologic classification of leukemia and lymphoma", Blood, 68: 1, 1986.
Han et al. "Chronic lymphocytic leukemia", in Henderson ES, Lister TA (eds): Leukemia, Philadelphia, PA, Saunders, 1990, p. 565.
Seon et al. "Monoclonal antibody that defines a unique human T-cell leukemia antigen", Proc. Natl. Acad. Sci. USA, 80: 845, 1983.
Takeuchi et al. "Monoclonal antibody SN10 which shows a highly selective reactivity with human B leukemia-lymphoma and is effectively internalized into cells", Cancer Res., 51:2985, 1991.
Haruta et al. "Distinct human leukemia-associated cell surface glycoprotein GP160 defined by monoclonal antibody SN6", Proc. Natl. Acad. Sci., USA, 83: 7898, 1986.
Fukukawa et al. "New monoclonal antibodies SN3, SN3a and SN3b directed to sialic acid of glycoprotein on human non-T leukemia cells" Exp Hematol 14: 850, 1986.
Luo et al. "Establishment of ascitic tumor of human pre-B acute lymphoblastic leukemia in nonconditioned nude mice", Cancer Res., 49: 706, 1989.
Matsuzaki et al. "Unique epitopes of common acute lymphoblastic leukemia antigen detected by new monoclonal antibodies", Cancer Res., 47: 2160, 1987.
Seon et al. "Human T cell leukemia antigens on the cell membranes: Purification, molecular characterization, and preparation of specific antisera", J. Immunol, 127: 2580, 1981.
Negoro et al. "Strong, specific anti-human leukemia antisera prepared with the use of purified cell membrane antigen", Cancer Res., 41: 2973, 1981.
Seon et al. "Monoclonal antibody SN2 defining a human T-cell leukemia-associated cell surface glycoprotein", J. Immunol., 132: 2089, 1984.
Sunaga et al. "Detection of sulfur-containing compounds in control and cadmium-exposed rat organs by high-performance liquid chromatography-vacuum-ultraviolet inductively coupled plasma-atomic emission spectrometry (HPLC-ICP)", Anal. Biochem., 160: 160, 1987.
Matsuzaki et al. "Molecular nature of a cell membrane antigen specific for human T-cell acute lymphoblastic leukemia", Cancer Res., 47: 4283, 1987.
Inman et al. "Characterization of Sequential immune complexes in infective endocarditis by Western blot analysis", J. Immunol, 133: 217, 1984.
Trucco et al. "Quantitative analysis of cell surface HLA structures by means of monoclonal antibodies", Human Immunol., 3: 233, 1980.
Seon et al. "Human T-cell leukemia-associated cell surface glycoprotein GP37: Studies with three monoclonal antibodies and a rabbit antiserum", Mol. Immunol., 23: 569, 1986.
Luo et al. "Marked difference in the in vivo antitumor efficacy between two immunotoxins targeted to different epitopes of common acute lymphoblastic leukemia antigen (CD10): Mechanisms involved in the differential activities of immunotoxins", J. Immunol., 145: 1974, 1990.
Hara et al. "Efficient transplantation of human non-T-leukemia cells into nude mice and induction of complete regression of the transplanted distinct tumors by ricin A-chain conjugates of monoclonal antibodies SN5 and SN6", Cancer Res., 48: 4673, 1988.
Knowles et al. "Purification of immunotoxins containing ricin A-chain and abrin A-chain using Blue Sepharose CL-6B", Anal. Biochem., 160: 440, 1987.
Boyse et al. "Antigenic properties of experimental leukemias. II. Immunological studies in vivo with C57BL/6 radiation-induced leukemias" J. Natl. Cancer Inst., 31: 987, 1963.
Ritz et al. "Modulation of human acute lymphoblastic leukemia antigen induced by monoclonal antibody in vitro" J. Immunol., 125: 1506, 1980.
Zola, "The surface antigens of human B lymphocytes", Immunol. Today, 8: 308, 1987.
Magrath et al. "Bone marrow involvement in Burkitt's lymphoma and its relationship to acute B-cell leukemia" Leukemia Res., 4: 33, 1979.
LeBien et al. "Use of monoclonal antibodies, morphology, and cytochemistry to probe the cellular heterogeneity of acute leukemia and lymphoma" Cancer Res., 41: 4776, 1981.
Jaffe "The role of immunophenotypic markers in the classification of non-Hodgkin's lymphomas" Seminars Oncol., 17: 11, 1990.
Luzzatto et al. "DNA rearrangements of cell lineage specific genes in lymphoproliferative disorders" Prog. Hematol., 14: 303, 1986.
Vitetta et al. "Redesigning nature's poison to create anti-tumor reagents" Science, 238: 1098, 1987.
Vallera et al. "Immunoconjugates" in Chiao JW (ed), Biological Response Modifiers and Cancer Research, New York, Dekker, 1988, p. 17.
Seon et al. "Anti-human leukemia monoclonal antibodies and immunotoxins for complete growth suppression of tumor cells in vitro and in vivo", in Torisu M, Yoshida T (eds); New Horizons of Tumor Immunotherapy, Amsterdam, Elsevier Science Publishers, 1989, p. 329.
Gold et al. "Stimulation of protein tyrosine phosphorylation by the B-lymphocyte antigen receptor", Nature, 345: 810, 1990.
Campbell et al. "Protein tyrosine phosphorylation is induced in murine B lymphocytes in response to stimulation with anti-immunoglobulin", EMBO J., 9: 2125, 1990.
Clark et al. "Regulation of human B-cell activation and adhesion" Annu. Rev. Immunol., 9: 97, 1991.
Cambier et al. "Membrane immunoglobulin and its accomplices: new lessons from an old receptor" FASEB J., 6: 3207, 1992.
Reth, "Antigen receptors on B lymphocytes", Annu. Rev. Immunol., 10: 97, 1992.
Pernis et al. "Immunoglobulins as cell receptors" Ann. N.Y. Acad. Sci. 190: 420, 1972.
Hombach et al. "A novel 34 kD protein co-isolated with IgM molecule in surface IgM-expressing cells" EMBO J. 7: 3451, 1988.
Hombach et al. "Molecular components of the B-cell antigen receptor complex of the IgM class" Nature, 343: 760, 1990.
Campbell et al. "B lymphocyte antigen receptors (mlg) are non-covalently associated with a disulfide-linked, inducibly phosphorylated glycoprotein complex", EMBO J. 9: 441, 1990.
Sakaguchi et al. "B lymphocyte lineage restricted expression of mb-1, a gene with CD3-like structural properties" EMBO J., 7: 3457, 1988.
Hermanson et al. "A member of the immunoglobulin gene superfamily exclusively expressed on B-lineage cells" Proc. Natl. Acad. Sci. USA, 85: 6890, 1988.
Hombach et al. "Identification of the genes encoding the IgM-.
Dunn Michael L.
Health Research , Inc.
Scheiner Toni R.
LandOfFree
Monoclonal antibodies that define a unique antigen of human B ce does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Monoclonal antibodies that define a unique antigen of human B ce, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Monoclonal antibodies that define a unique antigen of human B ce will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-598559