Monoclonal antibodies that bind to and neutralize dimeric but no

Details Monoclonal antibodies that bind to and neutralize dimeric but no Monoclonal antibodies that bind to and neutralize dimeric but no

1993-11-19

1996-02-13

Hutzell, Paula K.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

43524027, 4351722, 435 7021, 53038823, 5303892, 53038815, G01N 3353, C07K 1624, C12N 520

Patent

active

054910650

ABSTRACT:
Monoclonal antibodies that bind to an apparent conformational epitope associated with recombinant or native dimeric M-CSF with concomitant neutralization of biological activity, which monoclonal antibodies are substantially unreactive with biologically inactive forms of M-CSF including monomeric and chemically derivatized dimeric M-CSF, are described. Methods of using the antibodies in assays for detection of dimeric M-CSF are also described.

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