Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1986-04-08
1990-01-16
Moskowitz, Margaret
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
43524027, 435 7021, 4351722, 435 7, 436548, 935104, 935110, C07K 1500
Patent
active
048944424
ABSTRACT:
A monoclonal antibody specific for an .alpha..sub.1 -acid glycoprotein or for at least one antigenic determinant included in a sugar chain of the following formula: ##STR1## wherein Gal means galactose, GlcNAc means N-acetylglucosamine, Man means mannose, Fuc means fucose, and n is 0 or 1, which is useful for the measurement of glycoproteins in cells, tissues and blood and therefore is useful for diagnosis of various diseases, particularly tumors, and a method for the production thereof by fusing a neoplasm cell line with antibody-producing cells from an animal which has been immunized against an desialylated glycoprotein and culturing the resultant hybridoma.
REFERENCES:
Young, W. W. et al., "Production of Monoclonal Antibodies Specific for Two Distinct Steric Portions of the Glycolipid Gauglio--N-Triosylceramide (Asialo GM.sub.2)," J. Exp. Med., 150:1008-1019, Oct. 1979.
Ochi, Y. et al. (II), "Immunological Similarity of CEA with .alpha..sub.1 -Acid Glycoprotein (Orosomucoid)," Clinica Chemica Acta, 122:145-160, 1982.
Kupchik, H. Z. et al., "Monoclonal Antibodies to Carcinoembryonic Antigen Produced by Somatic Cell Fusion," Cancer Research, 41:3306-3310, Sep., 1981.
Ochi, Y. et al. (I), "Immunochemical Identification of an .alpha..sub.1 -Acid Glycoprotein-Autigenic Determinant on Carcinoembryonic Antigen (CEA) and Non-Specific Cross-Reacting Antigen (NCA)," Clinica Chemica Acta, 138:9-9, 1984.
Federation Proceedings (U.S.), vol. 45, No. 6, p. 1574, (1986).
Clinical Research (U.S.), vol. 33, No. 2, Part 1, p. 193A, (1985).
Clinical Research (U.S.), vol. 33, No. 1, p. 9A, (1985).
Chemical Abstracts 98:51676F, (1983).
Chemical Abstracts 94:203339f, (1981).
Chemical Abstracts 97:90148j, (1982).
Tanihara Masao
Toyama Sakuji
Cheney Kay E.
Kuraray Co. Ltd.
Moskowitz Margaret
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