Monoclonal antibodies specific to in vivo fragments derived from

Details Monoclonal antibodies specific to in vivo fragments derived from Monoclonal antibodies specific to in vivo fragments derived from

1987-08-10

1989-07-25

Moskowitz, Margaret

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

530387, 530388, 435 68, 435 70, 4351722, 43524027, 435188, 424 11, 424 858, 436518, 436542, 436540, 436537, 436543, 436544, 436545, 935 95, 935104, 935108, 935110, C07K 1504, A61K 39395, G01N 33577, C12N 510

Patent

active

048513342

ABSTRACT:
Hybridoma for production of monoclonal antibody to an antigen found on the peptide fragment of the B.beta. chain of human fibrinogen or fibrin I containing amino acid residues 1-42. The hybridoma is formed by fusing an animal myeloma cell, e.g., mouse myeloma cell, with a splenocyte from an animal, e.g., a mouse, immunized with an NH.sub.2 -terminal of human fibrinogen or fibrin I. Hybridoma for production of monoclonal antibody to an antigen found on the peptide fragment of the B.beta. chain of human fibrin II containing amino acid residues 15-42. The hybridoma is formed by fusing an animal, e.g., mouse myeloma cell with a splenocyte from an animal, e.g., mouse, immunized with a NH.sub.2 -terminal of human fibrin II. Diagnostic and therapeutic uses of the monoclonal antibodies are also disclosed.

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