Monoclonal antibodies specific to in vivo fragments derived from

Details Monoclonal antibodies specific to in vivo fragments derived from Monoclonal antibodies specific to in vivo fragments derived from

1984-01-03

1988-02-02

Moskowitz, Margaret

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 13, 435 68, 435 70, 4351722, 435188, 43524027, 435241, 435810, 436518, 436537, 436540, 436542, 436545, 436548, 436804, 436815, 604 5, 530300, 530382, 530387, 530808, 935104, 935108, 935110, G01N 33577, C12N 500, C07K 1504

Patent

active

047229039

ABSTRACT:
Hybridoma for production of monoclonal antibody to an antigen found on the peptide fragment of the B.beta. chain of human fibrinogen or fibrin I containing amino acid residues 1-42. The hybridoma is formed by fusing an animal myeloma cell, e.g., a mouse myeloma cell, with a splenocyte from an animal, e.g., a mouse, immunized with an NH.sub.2 -terminal of human fibrinogen or fibrin I. Hybridoma for production of monoclonal antibody to an antigen found on the peptide fragment of the B.beta. chain of human fibrin II containing amino acid residues 15-42. The hybridoma is formed by fusing an animal, e.g., mouse myeloma cell with a splenocyte from an animal, e.g., mouse, immunized with a NH.sub.2 -terminal of human fibrin II. Diagnostic and therapeutic uses of the monoclonal antibodies are also disclosed.

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