Monoclonal antibodies specific to glactosyltransferase isoenzyme

Details Monoclonal antibodies specific to glactosyltransferase isoenzyme Monoclonal antibodies specific to glactosyltransferase isoenzyme

1985-12-02

1989-01-10

Warden, Robert J.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

4351722, 43524027, 436518, 436533, 436538, 436548, 436813, 530387, G01N 3353, G01N 33577, G07K 1514

Patent

active

047973560

ABSTRACT:
Murine monoclonal antibodies specific to the tumor marker galactosyltransferase II (GT-II) which have no measurable cross-reactivity with galactosyltransferase I (GT-I) are described. These antibodies are used in assays to determine levels of GT-II in serum or other body fluid samples, which levels, depending on their magnitude, are indicators of cancer.

REFERENCES:
patent: 4460561 (1984-07-01), Goldenberg
Podolsky, D. K. et al, Proc. Natl. Acad. Sci. USA (1984), 81:2529-2533.
Chatterjee, S. K., et al, Cancer Res. (1984), 44:5725-5732.

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