Monoclonal antibodies specific for the E2 glycoprotein of...

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

Reexamination Certificate

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C530S387100, C530S388100, C424S141100, C424S147100, C424S149100, C435S005000, C435S007100, C435S069100

Reexamination Certificate

active

06924362

ABSTRACT:
The present invention describes the identification and characterization of five human HC E1-specific monoclonal antibodies isolated from a phage display library and their use in the diagnosis, treatment, and prevention of HCV in mammals, preferably humans.

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Burioni R. et al. 1998 Dissection of human humoral immune response against hepatitis C virus E2 glycoprotein by repertoire cloning and generation of recombinant Fab fragments.Hepatology28(3):810-814.
Chan SW. et al. 1996 Human recombinant antibodies specific for hepatitis C virus core and envelope E2 peptides from an immune phage display library.J Gen Virol.77(Pt10):2531-2539.
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Hadlock KG. et al. 2000 Human monoclonal antibodies that inhibit binding of hepatitis C virus E2 protein to CD81 and recognize conserved conformational epitopes.J Virol.74(22):10407-10416.
Plaisant P. et al. 1997 Human monoclonal recombinant Fabs specific for HCV antigens obtained by repertoire cloning in phage display combinatorial vectors.Res Virol.148(2):165-169.
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