Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Animal cell – per se – expressing immunoglobulin – antibody – or...
Reexamination Certificate
2011-05-31
2011-05-31
Bunner, Bridget E (Department: 1647)
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Animal cell, per se, expressing immunoglobulin, antibody, or...
C435S331000, C435S334000, C530S350000, C530S387100, C530S387300, C530S388100, C530S388220, C530S391300
Reexamination Certificate
active
07951589
ABSTRACT:
The present invention describes monoclonal antibodies specific for the chemotactic epitope of the uPAR. In particular, the invention comprises monoclonal antibodies against uPAR fragments specifically recognizing in whole or in part the chemotactic sequence of uPAR connecting domain 1 to domain 2.
REFERENCES:
patent: WO 02/058714 (2002-08-01), None
Colcher et al. Effects of genetic engineering on the pharmacokinetics of antibodies. Q J Nucl Med 43(2): 132-139, 1999.
Sidenius et al. Shedding and cleavage of the urokinase receptor (uPAR): identification and characterisation of uPAR fragments in vitro and in vivo. FEBS Letter 475: 52-56, 2000.
Carriero et al. Tissue distribution of soluble and receptor-bound urokinase in human breast cancer using a panel of monoclonal antibodies. Cancer Res 54: 5445-5454, 1994.
Furlan et al. The soluble D2D3(88-274) fragment of the urokinase receptor inhibits monocyte chemotaxis and integrin. independent cell adhesion. J Cell Sci 117: 2909-2916, 2004.
Resnati et al. Specific immunofluorimetric assay detecting the chemotactic epitope of the urokinase receptor (uPAR). J Immunol Methods 308: 192-202, 2006.
Albrecht et al. “CD87 Workshop: Epitope-mapped monoclonal antibodies directed to the human urokinase receptor (uPAR, CD87)”. Leucocyte Typing VI: White cell differentiation antigens: proceedings of the 6thinternational workshop and conference held in Kobe, Japan, Nov. 10-14, 1996. Garland Pub: New York, 1997, pp. 1023-1025.
Blasi Francesco
Pallavicini Isabella
Resnati Massimo
Sidenius Nicolai
Bunner Bridget E
Rothwell Figg Ernst & Manbeck P.C.
Wilex AG
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