Chemistry: molecular biology and microbiology – Spore forming or isolating process
Patent
1988-09-27
1992-07-28
Doll, John J.
Chemistry: molecular biology and microbiology
Spore forming or isolating process
53038825, 530413, 435 7021, 4351722, C12N 520, C07K 1528, C07K 320, C12P 2108
Patent
active
051340763
ABSTRACT:
Monoclonal antibodies having a specificity for protease nexin-1 are described. Preferably an antibody has specificity to the reactive protease-binding site. The antibody is used in the affinity purification of PN-1 to produce large quantities of substantially pure PN-1, free of other biologically active molecules. Over a 2000-fold purification of a crude preparation of PN-1 may be obtained. The affinity-purified PN-1 is suitable for use in pharmacological preparations used in the treatment of neurological disease associated with serine protease-mediated inhibition of regenerative processes.
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Cunningham Dennis D.
Van Nostrand William E.
Wagner Steven L.
Doll John J.
Hutzell Paula
The Regents of the University of California
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