Monoclonal antibodies specific for non-A1C glycated hemoglobin a

Details Monoclonal antibodies specific for non-A1C glycated hemoglobin a Monoclonal antibodies specific for non-A1C glycated hemoglobin a

1990-02-27

1993-02-02

Chan, Y. Christina

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

5303887, 4351722, 435 7021, 43524027, C12P 2108, C07K 1528, C12N 520, G01N 3353

Patent

active

051837390

ABSTRACT:
Monoclonal antibodies specific for an epitope found on hemoglobin glycated both in vivo and in vitro but not found on hemoglobin A.sub.o or hemoglobin A.sub.1c are provided. Use of these antibodies to measure glycohemoglobin levels in the blood provides a measure of the glucose levels in the erythrocyte for the previous 90-120 days. No reduction of the blood sample is required to produce the epitope recognized by the monoclonal antibodies.

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Johnson et al., "Fructosamine: A New Approach to the Estimation of Serum Glycosylprotein, An Index of Diabetic Control," Clinica Chimica Acta, (1982), 127:87-95.
San-Gil et al., "Improved Estimation of Fructosamine, as a Measure of Glycated Serum Protein, with the Technicon RA-1000 Analyzer," Clin. Chem., (1985), 31:2005-20006.
Nakayama et al., "Quantitative Enzyme-Linked Immunosorbent Assay (ELISA) for Non-Enzymatically Glycated Serum Protein," J. Immunol. Meth. (1987), 99:95-100.

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