Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Enzymatic production of a protein or polypeptide
Patent
1983-02-28
1986-04-15
Marantz, Sidney
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Enzymatic production of a protein or polypeptide
435 41, 4351722, 435240, 435241, 935101, 935103, C12N 500, C12N 1500
Patent
active
045827974
ABSTRACT:
Monoclonal antibodies are produced for a family of glycoproteins which are selectively expressed on the surface of nucleated human hematopoietic cells but which are absent from other normal human cells. Mice are inoculated with human hematopoietic cells or fragments thereof, and spleen cells obtained from the mice are fused with murine myeloma cells to produce hybridomas. The hybridomas are cultured as clones, and antibodies obtained from the individual clones are tested for their specificity for surface glycoproteins of nucleated human hematopoietic cells. Antibodies can be obtained from the culture growth medium or from ascitic fluid of mice bearing the hybridoma tumor and can be used to distinguish lymphomas from carcinomas.
REFERENCES:
patent: 4172124 (1979-10-01), Koprowski
patent: 4196265 (1980-04-01), Koprowski
patent: 4271145 (1980-06-01), Wands
patent: 4361549 (1982-11-01), Kung
patent: 4363799 (1982-12-01), Kung
patent: 4364933 (1982-12-01), Kung
patent: 4364935 (1982-12-01), Kung
patent: 4364936 (1982-12-01), Kung
patent: 4364937 (1982-12-01), Kung
Kohler, C. et al., Eur. J. Immunol., 6, 511-519, (1976).
Melchers, F. et al., Second Workshop on "Functional Properties of Tumors of T and B Lymphocytes", Apr. 3-5, 1978, Bethesda, Md., pp. IX-XIX.
Trowbridge, I. S., "Interspecies Spleen-Myeloma Hybrid Producing Monoclonal Antibodies . . . ", J. Exp. Med., 1978, 313-323.
Borowitz, M. J. et al., Human Pathology, 15 (10), 928-934, (Oct. 1984).
Marantz Sidney
The Salk Institute for Biological Studies
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