Monoclonal antibodies specific for HIV and the hybridomas for pr

Details Monoclonal antibodies specific for HIV and the hybridomas for pr Monoclonal antibodies specific for HIV and the hybridomas for pr

1994-07-01

1997-12-09

Budens, Robert D.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

435 724, 53038815, 53038835, C12Q 170

Patent

active

056959273

ABSTRACT:
Human monoclonal antibodies which belong to the IgG1 subclass and are specific for HIV are described. The monoclonal antibodies have potential for use in the diagnosis, prevention and therapy of HIV infection.

REFERENCES:
Fahey et al, "Status of Immune-based Therapies in HIV Infection and AIDS," Clin. Exp. Immunol. 88:1-5, 1992.
Tilley et al., "A Human Monoclonal Antibody Against the CD4-binding Site of HIV1 gp120 Exhibits Potent, Broadly Neutralizing Activity", Res. Virol. 142:247-259, 1991.
Posner et al., "AnIgG Human Monoclonal Antibody That Reacts With HIV1/gp120, Inhibits Virus Binding to Cells, and Neutralizes Infection," J. Immunol. 146(12):4325-4332, Jun. 15, 1991.
Robinson et al., "Identification of Conserved and Variant Epitopes of Human Immunodeficiency Virus Type 1 (HIV-1) gp120 by Human Monoclonal antibodies Produced by EBV-Transformed Cell Lines," AIDS Res. Human Retroviruses 6(5):567-577, 1990.

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