Monoclonal antibodies specific for crack cocaine...

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

Reexamination Certificate

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C530S403000, C530S409000, C530S807000, C530S809000, C435S070210, C435S345000, C435S354000, C435S961000, C436S548000

Reexamination Certificate

active

07105643

ABSTRACT:
A monoclonal antibody, and a cell line capable of producing the same, has been produced with the ability to detect the primary metabolites generated from the pyrolysis of smokeable, or “crack”, cocaine. This monoclonal antibody, while being highly specific for anhydroecgonine methyl ester (AEME) and ecgonidine (ECD), does not cross-react at a significant level with the primary cocaine metabolites of powdered or injected cocaine. Also, crack cocaine conjugates capable of evoking an immune response in animals have been produced.

REFERENCES:
patent: 3888866 (1975-06-01), Leute et al.
patent: 4197237 (1980-04-01), Leute et al.
patent: 4207307 (1980-06-01), Kaul et al.
patent: 5808074 (1998-09-01), Gowda et al.
patent: 6174723 (2001-01-01), Yugawa et al.
patent: 6271381 (2001-08-01), Yugawa et al.
patent: 6541004 (2003-04-01), Scherrmann et al.
patent: WO 97/21451 (1997-06-01), None
William R. Thistle. Physchemidics RIA cocaine assay. 510 (K) summary, Nov. 6, 2001.
Lu, Natalie, “Distinguishing Crack Use From Powder Cocaine: Indentification of Unique Pyrolysis Products from Crack Use In Urine”, Apr. 26-30, 1999.
Jacob, Peyton III, et al., “A pyrolysis Product, Anhydroecgonine Methyl Ester (Methylecgonidine), is in the Urine of Cocaine Smokers”, Journal of Analytical Toxicology, vol. 14, Nov./Dec. 1990.
Cone, Edward J., et al., “simultaneous Measurement of Cocaine, Cocaethylene, Their Metabolites, and “Crack” Pyrolysis Products by Gas Chromatography-Mass Spectrometry”, 1994, pp. 1299-1305, vol. 40/7.
Levin, Barry, et al., “Stability of Ecgonine Methyl Ester in Postmortem Urine Specimens”, Journal of Forensic Science, JFSCA, vol. 41, No. 1, Jan. 1996, pp. 126-128.
Riley, K. Jack, Natalie T. Lu, et al., “Monitoring the Crack Epidemic through Urine Testing: Establishment of Routine Detection Methods”, Addiction Biology, 2001, pp. 83-95.
Pascal, Kintz, et al., “Testing Human Hair and Urine for Anhydroecgonine Methyl Ester, a Pyrolysis Product of Cocaine”, Journal of Analytical Toxicology, vol. 19, Oct. 1995 pp. 479-482.
Cone, Edward, Validity of Commercial Urine Cocaine Metabolite Assays: III. Evaluation of an Enzyme-Linke Immunosorbent Assay (ELISA) for Detection of Cocaine and Cocaine Metabolite Journal of Forensic Sciences, vol. 34, No. 4, Jul. 1989, pp. 991-995.
Cone, Edward, et al., Validity Testing of Commercial Urine Cocaine Metabolite Assays: IV. Evaluation of the EMIT d.a.u. Cocaine Metabolite Assay in Quantitative Mode for Detection of Cocaine Metabolie, Journal of Forensic Sciences, vol. 35, No. 4, Jul. 1990, pp. 786-791.
Romberg, Robert W. and Past, M.R., “Reanalysis of Forensic Urine Specimens Containing Benzoylecgonine and THC-COOH”, Journal of Forensic Sciences, vol. 39, No. 2, Mar. 1994 pp. 479-485.
Jeffcoat, Robert A., et. al., “Cocaine Disposition in Humans After Intravenous Injection, Nasal Insufflation (Snorting), or Smoking”, Drug Metabolism and Disposition, vol. 17, No. 2, 1989 pp. 153-159.
Martinez, Francisca, et al., Cocaine Metabolite (Benzoylecgonine) in Hair and Urine of Drug Users, Journal of Analytical Toxicology, vol. 17, May/Jun. 1993, pp. 138-142.

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