Chemistry: analytical and immunological testing – Involving immune complex formed in liquid phase – Separation of immune complex from unbound antigen or antibody
Patent
1988-12-28
1990-10-02
Draper, Garnette D.
Chemistry: analytical and immunological testing
Involving immune complex formed in liquid phase
Separation of immune complex from unbound antigen or antibody
435 4, 435 7, 4351722, 43524027, 436501, 436504, 436513, 436516, 436528, 436529, 436530, 436531, 436532, 436533, 436534, 436535, 436540, 436548, 436813, 530387, 530388, 530395, 530828, A61K 39395, C07K 1528, G01N 33536, G01N 33574
Patent
active
049607162
ABSTRACT:
A substantially pure antigen found on normal and benign breast epithelial cell membranes and in breast cancer cells, fused cell hybrids which produce antibodies specific for such antigen, the monoclonal antibodies produced by such fused cell hybrids, a method for detecting the presence of breast cancer in a patient which is based on measuring the concentrations of one or more determinants of such antigen in a patient sample, and a method for either identifying those breast cancer patients whose tumors would respond to estrogen manipulation or determining prognosis based on the degree of differentiation, which method is based on measuring the concentration of an estrogen-modulated determinant of such antigen.
REFERENCES:
patent: 4584268 (1986-04-01), Ceriani
patent: 4657851 (1987-04-01), Feller
Ceriani et al., "Surface Differentiation Antigen of Human Epithelial Cells, Carried on the Human Milk Fat Globule", Proc. Nat. Acad. Sci. U.S.A. 74(2), pp. 582-586 (1977).
Taylor-Papadimitrious et al., "Monoclonal Antibodies to Epithelial-Specific Components of the Human Milk Fat Globule Membrane: Production and Reaction with Cells in Culture", Int. J. Cancer 28, pp. 17-21 (1981).
Arklie et al., "Differention Antigens Expressed by Epithelial Cells in the Lactating Breast are also Detectable in Breast Cancers", Int. J. Cancer 28, pp. 23-29 (1981).
Peterson et al., "Analogues of Expression of Human Mammary Epithelial Antigens in Normal and Malignant Breast Cells at the Single Cell Level by Flow Cytofluorinity", Expl. All. Biology 49: 1-14 (1981).
Ceriani et al., "Circulating Human Mammary Epithalial Antigens in Breast Cancer", Prod. Nat. Acad. Sci. U.S.A. 79, pp. 5420-5424 (1982).
Ashall et al., "A New Marker for Human Cancer Cells. 1. The Ca Antigens and the Ca1 Antibody", The Lancet, Jul. 3, 1982, pp. 1-6.
McGee et al., "A New Marker for Human Cancer Cells 2. Immunohistochemical Detection of the Ca Antigen in Human Tissues with Cal Antibody", The Lancet, Jul. 3, 1982, pp. 7-10.
Ceriani et al., "Characterization of All Surface Antigens of Human Mammary Epithelial Cells with Monoclonal Antibodies Prepared Against Human Milk Fat Globule", Somatic Cell Genetics, 9 (4), pp. 415-427 (1983).
Burchell et al., "Complexity of Expression of Antigenic Determinate, Recognized by Monoclonal Antibodies HMFG-1 and HMFG-2, In Normal and Malignant Human Mammory Epithelial Cells", J. Immunology 131 (1), pp. 508-513 (1983).
Harvey Michael A.
Luderer Albert A.
Manning Brenda D.
Nicholson Mary L.
Travis Karen L.
Ciba Corning Diagnostics Corp.
Draper Garnette D.
Kushan Jeff
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