Chemistry: molecular biology and microbiology – Spore forming or isolating process
Patent
1988-12-30
1993-06-08
Doll, John J.
Chemistry: molecular biology and microbiology
Spore forming or isolating process
53038824, 5303911, 5303913, 435 7021, 4351722, C12N 520, C12N 1502, C07K 1528, C12P 2108
Patent
active
052178960
ABSTRACT:
This invention provides a monoclonal antibody which specifically forms a complex with amino acids 1-87 of PTHLP which does not form a complex with amino acids 1-34 of PTHLP, and which forms a complex with the epitope to which any of the monoclonal antibodies produced by the hybridomas 212-10.7, (ATCC Accession No. HB9930), 199-999 (ATCC Accession No. HB9929), 199-278 (ATCC Accession No. HB9931), is directed.
This invention further provides methods of detecting PTHLP and of diagnosing and treating humoral hypercalcemia of malignancy.
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Burtis, W. J. et al., (1987) J. Biol. Chem. 262:7157.
Moseley, J. M. et al., (1987) Proc. Natl. Acad. Sci. USA 84: 5048.
Nissenson, R. A. et al., (1988) J. Biol. Chem. 263: 12866.
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Weir et al. Endocrinology 123(6):2744-2751 1988.
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Morrison, Science 229:1202-1207, 1985.
Buck et al. in Kennett et al Eds. Monoclonal Antibodies and Functional Cell Lines Plenum Press, 1984.
Kramer Steven P.
Reynolds, Jr. Frederick H.
Sorvillo John M.
Valenzuela David M.
Cobert Robert J.
Doll John J.
Hutzell Paula
Oncogene Science, Inc.
White John P.
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