Monoclonal antibodies recognizing L-thyroxine

Details Monoclonal antibodies recognizing L-thyroxine Monoclonal antibodies recognizing L-thyroxine

1984-07-16

1987-01-13

Warren, Charles F.

Chemistry: analytical and immunological testing

Thyroid hormone tests

436518, 436528, 436531, 436545, 436548, 436804, 436811, 436817, 436822, 436823, G01N 33577, G01N 33543

Patent

active

046364781

ABSTRACT:
Monoclonal antibodies specific for thyroxine (T.sub.4) are produced by two new and separate hybridoma cell lines. Combinations of the monoclonal antibodies from the two cell lines are used in an immunoassay for T.sub.4 of high accuracy over the range of T.sub.4 concentrations encountered in serum samples.

REFERENCES:
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Yalow, R. S., Radioimmunoassay, Hutchinson Ross Publishing Co, Pa., (1983), pp. 5-25.
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Mallinkrodt, SPAC.RTM. T4 Product Literature, Immunoassay Systems, St. Louis, Mo., (1982).
Ehrlich, P. H. et al, J. of Immunology, vol. 128(6), 2709-2713, (6-1982).
Katus, H. A. et al, Molecular Immunology, vol. 19(3), 451-455, (1982).

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