Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Monoclonal antibody or fragment thereof
Reexamination Certificate
2005-10-04
2005-10-04
Chin, Christopher L. (Department: 1641)
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Monoclonal antibody or fragment thereof
C424S133100, C424S152100, C424S153100, C435S070210, C435S452000, C435S328000, C435S334000, C435S343000, C530S387300, C530S388220, C530S388700
Reexamination Certificate
active
06951645
ABSTRACT:
A “cocktail” combination of two monoclonal antibodies respectively acting on different sites of the platelet GPIIb-IIIa complex has been disclosed. This “cocktail” combination can completely block receptor function of the GPIIb-IIIa complex, inhibit platelet aggregation and thereby efficiently inhibit thrombosis.
REFERENCES:
patent: 5387413 (1995-02-01), Coller
patent: 5770198 (1998-06-01), Coller et al.
patent: 5777085 (1998-07-01), Co et al.
patent: 1297816 (1992-03-01), None
patent: 557535 (1997-12-01), None
Becker, Richard C.,Thrombin Antagonists and Antiplatelet Agents, Am J Cardiol 1932;69:39A-51A.
Coller, Barry S.,Progress in Hemostasis and Thrombosis, 1989; vol. 9:117-124.
Knight, David M., et al,The Immunogenicity of the 7E3 Murine Monoclonal FAB Antibody Fragment Variable Region is Dramatically Reduced in Humans by Substitution of Human for Murine Constant Regions, Molecular Immunology, vol. 32, No. 16, pp. 1271-1281, 1995.
Verstraete, Marc,Synthetic Inhibitors of Platelet Glycoprotein IIb/IIIa In Clinical Development, Circulation, 2000;102:e76-e80
Changgeng, Ruan,Monoclonal Antibodies and Thrombotic Diseases, Science and Technology at the Frontier in China, [Ed. By Chinese Engineering Academy] 2001; vol. 4: 131-145.
Coller, Barry S., et al,A Murine Monocional Antibody That Completely Blocks the Binding of Fibrinogen to Platelets Produces a Thrombasthenic-like State in Normal Platelets and Binds to Glycoproteins lib and/or IIIa, J. Clin.Invest. 1983; vol. 72(1):325-338.
Ruan Changgeng
Ye George Qingwei
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