Monoclonal antibodies reactive with specific antigenic sites on

Details Monoclonal antibodies reactive with specific antigenic sites on Monoclonal antibodies reactive with specific antigenic sites on

1987-08-07

1992-06-30

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Lymphokine

A61K 3900

Patent

active

051261308

ABSTRACT:
The present invention is directed to a composition containing a first monoclonal antibody, capable of neutralizing human cytomegalovirus (HCMV), that binds to a first epitope on HCMV GCA, and a second non-neutralizing HCMV monoclonal antibody that binds to a second epitope on HCMV GCA. The GCA complex includes antigenically-related glycoproteins of molecular weights 130,000, 93,000, and 50,000-52,000 kDa. The mixture of the two antibodies has greater neutralizing activity than a composition containing the first antibody alone. Also provided is a method for neutralizing the infectivity of HCMV using the composition.

REFERENCES:
patent: 3959466 (1976-05-01), Plotkin
F. R. Cockerill III, Mayo Clin. Proc., 60, 636 (1985).
Shuster et al., Mayo Clin. Proc., 60, 577 (1985).
Rasmussen et al., Proc. Nat'l. Acad. Sci. USA, 81, 876 (1984).
Rasmussen et al., Journal of Virology, 55, 274 (1985).
Kim et al., Journal of Virology, 20, 604 (1976).
Kim et al., Journal of Clinical Microbiology, 18, 331 (1983).
Britt, Virology, 135, 369 (1984).
Law et al., Journal of Medical Virology, 17, 255 (1985).
L. Pereira et al., Infection and Immunity, 36, 924 (1982).
B. Kari et al., J. Virology, 60, 345 (Nov. 1986).
W. J. Britt et al., J. Virol., 58, 185 (1986).
G. Farrar et al., J. Gen. Virol., 67, 1469 (1986).
The EMBO Journal, vol. 5, No. 11, 1986, IRL Press Limited (Oxford, GB), M. P. Cranage et al.: "Identification of the Human Cytomegalovirus Glycoprotein B. Gene and Induction of Neutralizing Antibodies via its Expression in Recombinant Vaccinia Virus", pp. 3057-3063.

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