Monoclonal antibodies reactive with a cell-surface gylcoprotein

Details Monoclonal antibodies reactive with a cell-surface gylcoprotein Monoclonal antibodies reactive with a cell-surface gylcoprotein

1988-10-19

1992-12-15

Saunders, David A.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

435 7021, 4351722, 43524027, 435948, 435 723, 436548, 436813, 530395, 530806, 530809, 530828, 53038885, 530861, 530862, 530864, 935104, C07K 1528, C12N 520, G01N 33574, G01N 33577

Patent

active

051716666

ABSTRACT:
The present invention relates to a novel tumor-associated antigen that is a cell-surface glycoprotein having a molecular weight in the range of 110,000-140,000 daltons that is present in a variety of carcinomas, including squamous cell carcinomas and adenocarcinomas. The invention also comprises antibodies reactive with the antigen, hybridoma cell lines that produce the antibodies of the invention, and methods for using the antibodies in the diagnosis and treatment of cancer.

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