Monoclonal antibodies for treatment of human non-small cell lung

Details Monoclonal antibodies for treatment of human non-small cell lung Monoclonal antibodies for treatment of human non-small cell lung

1990-05-11

1992-02-25

Kepplinger, Esther L.

Drug, bio-affecting and body treating compositions

Lymphokine

424 8591, 530387, 530388, 530389, 530390, 530391, 530392, 530393, 530806, 530808, 530828, 43524027, 4351772, A61K 39395, C07K 1528

Patent

active

050911775

ABSTRACT:
The present invention is concerned with novel monoclonal antibodies which define a glycolipid antigen associated with human non-small cell lung carcinomas ("NSCLC") and certain other human carcinomas. The antibodies bind to normal human cells to a much lesser degree than to tumor cells. The antibodies find use in diagnostic methods such as the detection of malignant cells associated with NSCLC and in therapeutic methods. The invention also comprises a method for determining the presence of a malignant condition in lung tissue and other human tissue. The method involves examining the human tissue for the presence of a glycolipid antigen having the characteristics of a ganglio-N-triosylceramide.

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