Drug – bio-affecting and body treating compositions – Conjugate or complex of monoclonal or polyclonal antibody,...
Reexamination Certificate
2005-01-18
2005-01-18
Spector, Lorraine (Department: 1646)
Drug, bio-affecting and body treating compositions
Conjugate or complex of monoclonal or polyclonal antibody,...
C424S130100, C424S138100, C424S139100, C424S141100, C424S143100, C424S155100, C435S326000, C435S328000, C435S330000, C435S331000, C435S334000, C530S350000, C530S387100, C530S387300, C530S387700, C530S387900, C530S388220, C530S391300
Reexamination Certificate
active
06843990
ABSTRACT:
The invention provides monoclonal antibodies against decoy receptor 3 (DcR3), hybridomas producing said antibodies, kits containing said monoclonal antibodies and uses of the hybridomas, antibodies and kits for the detection of DcR3-associated diseases, as well as for the treatment and/or prevention of DcR3-associated diseases.
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Yoshikawa et al., Human monoclonal antibody reactive to stomach cancer produced by mouse-human hybridoma technique, Jap. J. Cancer Res. 77(11):1122(abstract), Nov. 1986.*
Yu, K.Y. et al., “A Newly Identified Member of Tumor Necrosis Factor Receptor Superfamily (TR6) Suppresses LIGHT-mediated Apoptosis,” J. Biol. Chem. 274(20):13733-13736, 1991.
Sheikh, M.S. et al., “Death and Decoy Receptors and p53-mediated Apoptosis,” Leukemia 14:1509-1513, 2000.
Green, Douglas, “Death Deceiver,” Nature 396-629-630, 1998.
Pitti, Robert M. et al., “Genomic Amplification of a Decoy Receptor for Fas Ligand in Lung and Colon Cancer,” Nature 396:699-702, 1998.
Chang B. et al., “Overexpression of M68/DcR3 in Human Gastrointestinal Tract Tumors Independent of Gene Amplification and Its Location in Four-Gene Cluster,” PNAS 97(3):1230-1235, 2000.
Shen-Chih Mai
Shih-Jen Liu
Anawrahta Biotech Co.
Fish & Richardson P.C.
Kaufman Claire M.
Spector Lorraine
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