Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1992-03-27
1993-11-23
Kepplinger, Esther L.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
435 792, 435 793, 435 795, 436548, C07K 1500
Patent
active
052645568
ABSTRACT:
The present invention relates to an anti-idiotypic monoclonal antibody raised against a mouse monoclonal antibody or fragments thereof specific to at least one diarrhetic shellfish poisoning toxin selected from the group consisting of okadaic acid and derivatives thereof. The anti-idiotypic antibody is characterized by reacting only with antibodies to okadaic acid and derivatives thereof but not with antibodies directed against any other compounds. The anti-idiotypic antibody is further characterized by being an internal image of okadaic acid and derivatives thereof. A hybridoma producing an anti-idiotypic antibody in accordance with the present invention has been deposited at the ATCC under accession number HB 10768. Competitive solid-phase assays for determining the amount of okadaic acid and derivatives thereof in marine samples are also provided in accordance with the present invention. The present invention also relates to a kit for determining the amount of okadaic acid and derivatives thereof in marine samples.
REFERENCES:
patent: 4536479 (1985-08-01), Vander-Mallie
patent: 4699880 (1987-10-01), Goldstein
Uda, T. et al. "Enzyme Immunoassay Using Monoclonal Antibody Specific for Diarrhetic Shellfish Poisons", Mycotoxins and Phycotoxins '88 Elsevier Science Publishers B.V. Amsterdam, 1989, pp. 335-342.
Hokama, Y. et al. "Cross-Reactivity of Ciguatoxin, Okadais Acid, and Polyethers with Monoclonal Antibodies", Food & Agricultural Immunology, vol. 1 (1989) pp. 29-35.
Usagawa, T. et al. "Preparation of Monoclonal Antibodies Against Okadaic Acid Prepared from the Sponge Halichondria Okadai," Toxicon vol. 27, No. 12 (1989) pp. 1323-1330.
Shestowsky William S.
Sikorska Hanna
Kepplinger Esther L.
Rougier Inc.
Spiegel Carol A.
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