Monoclonal antibodies for human tissue cross-matching

Details Monoclonal antibodies for human tissue cross-matching Monoclonal antibodies for human tissue cross-matching

1982-08-18

1985-05-14

Kepplinger, Esther M.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435240, 435810, 4351722, 435948, 260112B, 260112R, 436548, 436821, 935 96, 935103, 935110, G01N 3354, C12N 500, C12N 1500, C12R 191, A61K 39395

Patent

active

045172897

ABSTRACT:
Immortal, antibody-producing, hybridomally-produced clones which produce antibodies that react specifically with human HLA antigens and which are produced from rat lymphocyte cells sensitized against cells from a rat strain having different histocompatibility antigens are disclosed along with methods of producing the clones and antibodies and methods of using the antibodies in tissue crossing tests.

REFERENCES:
patent: 4314026 (1982-02-01), Descamps-Latscha
patent: 4350683 (1982-09-01), Galfre et al.
McKearn et al., Monoclonal Antibodies, Plenum Publishing Co., N.Y. (1981), 219-234.
Howard et al., Immunol., 41:131-141, (1980).
Parham et al., Nature, 276:397-398, (1978).
Parham et al., J. Immunol., 123,(1):342-349, (1979).
Haynes et al., PNAS, USA, 76(11):5829-5833, (1979).
Eisen, Immunology, Harper & Row, Hagerstown, Md., 618, (1974).
Smilek et al., Journal of Experimental Medicine, 151, May 1980, pp. 1139-1150, "Monoclonal Rat Anti-Major Histocompatibility Complex Antibodies Display Specificity for Rat, Mouse, and Human Target Cells".
Nature, 266, Apr. 1977, pp. 550-552, Galfre et al., "Antibodies to Major Histocompatibility Antigens".

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