Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Animal cell – per se – expressing immunoglobulin – antibody – or...
Patent
1995-06-02
1998-11-17
Scheiner, Toni R.
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Animal cell, per se, expressing immunoglobulin, antibody, or...
5303871, 5303882, 5303891, C12N 520, C07K 1628
Patent
active
058375392
ABSTRACT:
The invention relates to isolated human mesenchymal stem cells, a method for isolating, purifying, and culturally expanding human mesenchymal stem cells (i.e. mesenchymal stem cells or "MSCs"), and characterization of (including by cytokine expression profiling) and uses, particularly research reagent, diagnostic and therapeutic uses for such cells. The stem cells can be culture expanded without differentiating. Further disclosed are monoclonal antibodies specific for human mesenchymal stem cells and the monoclonal hybridoma cell lines (ATCC nos. 10743-10745) that synthesize and secrete these monospecific antibodies, and uses of the monoclonal antibodies for diagnostic and/or therapeutic purposes.
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George-Weinstein, Dev. Biol 125/1 34-50, 1988.
Yonada & Pratt, Science 213:563-565, 1981.
Bruder and Caplan, Bone 11:189-198, 1990.
Bruder and Caplan Bone 10:359-375, 1989.
Kipps & Herzenberg Schemata for Production of monoclonal antibody Producing hybridomas. Ch 108 in Applications in Immundogical Methods., Weir, Ed. 1987.
Roitt "Immunology" J.B.Lippincott Co, Philadelphia 1989, Ch. 4 pp. 4.3 and 4.11.
Caplan Arnold I.
Haynesworth Stephen E.
Johnson Nancy A.
Olstein Elliot M.
Osiris Therapeutics, Inc.
Scheiner Toni R.
Semionow Raina
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