Monoclonal antibodies for human mesenchymal stem cells

Details Monoclonal antibodies for human mesenchymal stem cells Monoclonal antibodies for human mesenchymal stem cells

1998-05-19

2000-07-11

Johnson, Nancy A.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 72, 435 721, 5303882, 5303887, C07K 1618, C07K 1628, G01N 3353

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06087113&

ABSTRACT:
The invention relates to isolated human mesenchymal stem cells, a method for isolating, purifying, and culturally expanding human mesenchymal stem cells (i e. mesenchymal stem cells or "MSCs"), and characterization of (including by cytokine expression profiling) and uses, particularly research reagent, diagnostic and therapeutic uses for such cells. The stem cells can be culture expanded without differentiating. Further disclosed are monoclonal antibodies specific for human mesenchymal stem cells and the monoclonal hybridoma cell lines (ATCC nos. 10743-10745) that synthesize and secrete these monospecific antibodies, and uses of the monoclonal antibodies for diagnostic and/or therapeutic purposes.

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