Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Monoclonal antibody or fragment thereof
Reexamination Certificate
2008-09-02
2008-09-02
Gambel, Phillip (Department: 1644)
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Monoclonal antibody or fragment thereof
C424S130100, C424S146100
Reexamination Certificate
active
10574862
ABSTRACT:
Certain monoclonal antibodies are able to detect urinary trypsin inhibitors (UTIs) that are characteristic of disease in humans. In particular, the UTIs include AMBK, Bikunin, Uristatin, Uristatin-1, Uristatin-2, as defined herein, also including the fragments and aggregates thereof.
REFERENCES:
patent: 6242197 (2001-06-01), Papuashvili
patent: 6583108 (2003-06-01), Tamburini et al.
patent: 6673632 (2004-01-01), Ohshiro
patent: 2001/0055816 (2001-12-01), Rehm et al.
patent: 2002/0004219 (2002-01-01), Corey et al.
patent: 2003/0125577 (2003-07-01), Corey et al.
patent: 2003/0190732 (2003-10-01), Josic
patent: 10-70997 (1998-03-01), None
Trefz et al.; “Establishment of an enzyme-linked immuno-sorbent assay for urinary trypsin inhibitor by using a monoclonal antibody” Journal of Immunoassay, 12(3), 347-369 (1991).
Li et al. PNAS 77:3211-3214, 1980.
Lederman et al. 1991, Molecular Immunology 28:1171-1181.
Merck Manual [online]. Copyright © 1995-2007 Merck & Co., Inc., Whitehouse Station, NJ, USA. [retrieved on Apr. 18, 2007]. Retrieved from the Internet:<http://www.merck.com/mmpe/sec07/ch073/ch073c.html#sec07-ch073-ch073c-664>. Acute Coronary Syndromes (ACS); Diagnosis].
Bast, Jr. et al. Clinical Cancer Research, 2005, 11:6103-6108.
LaBaer et al. Journal of Proteome Research, 2005, 4:1053-1059.
Baker Nature Biotechnology, 2005, 23:297-304.
Pugia et al.; “Pathophysiology and diagnostic value of urinary trypsin inhibitors,”Clin Chem Lab Med, vol. 43 (1), 2005, pp. 1-16.
Zhu et al.; “Analysis of ligand binding by bioaffinity mass spectrometry,”Clinica Chimica Acta xx, (2006), xxx-xxx, CCA-10235; 8 pages.
Jortani et al.; “Sensitive Noninvasive Marker for the Diagnosis of Probable Bacterial or Viral Infection,”Journal of Clinical Laboratory Analysis, vol. 18 (2004) pp. 289-295.
Pugia et al.; “The uristatin dipstick is useful in distinguishing upper respiratory from urinary tract infections,”Clinica Chimica Acta, vol. 341 (2004) pp. 73-81.
Suzuki et al.; “Suppression of Invasion and Peritoneal Carcinomatosis of Ovarian Cancer Cell Line by Overexpression of Bikunin,”Int. J. Cancer, vol. 104, pp. 289-302, (2003).
Capon et al.; “In acute inflammation, the chondroitin-4 sulphate carried by bikunin is not only longer; it is also undersulphated,”Biochimie, vol. 85 (2003) pp. 101-107.
Kobayashi et al.; “Suppression of urokinase receptor expression by bikunin is associated with inhibition of upstream targets of extracellular signal-regulated kinase-dependent cascade,”Eur. J. Biochem., vol. 269, pp. 3945-3957 (2002).
Mizon et al.; “Urinary Bikunin Determination Provides Insight into Proteinase/Proteinase Inhibitor Imbalance in Patients with Inflammatory Diseases,”Clin Chem Lab Med 2002, vol. 40(6), pp. 579-586, 2002.
Kreft et al.; “Polarized Expression of Tamm-Horsfall Protein by Renal Tubular Epithelial Cells Activates Human Granulocytes,”Injection and Immunity, May 2002, pp. 2650-2656.
Suzuki et al.; “Kunitz-type Protease Inhibitor Bikunin Disrupts Phorbol Ester-induced Oligomerization of CD44 Variant Isoforms Containing Epitope v9 and Subsequently Suppresses Expression of Urokinase-type Plasminogen Activator in Human Chondrosarcoma Cells,”The Journal of Biological Chemistry, vol. 277 (10), Mar. 8, 2002, pp. 8022-8032.
Matsumi et al.; “Changes in Urinary Trypsin Inhibitor in Blood and Urine, as Well as Serum Cytokines in Living Related Liver Transplantation,”Department of Anesthesiology and Resuscitology, Ikayama University Graduate School of Medicine and Dentistry, Okayama 700-8558, Sep. 12, 2002, 12 pages.
Isogai et al.; “Quantitative analysis of bikunin-laden mast cells in follicular eruptions and chronic skin lesions of atopic dermatitis,”Arch Dermatol Res, (2002) vol. 294, pp. 387-392.
Tyagi et al.; “The Liver-Specific Human α1-Microglobulin/Bikunin Precursor (AMBP) is Capable of Self-Association,”Archives of Biochemistry and Biophysics, vol. 399 (1), Mar. 1, 2002, pp. 66-72.
Sugita et al.; “Effect of a human urinary protease inhibitor (Ulinastatin) on respiratory function in pediatric patients undergoing cardiopulmonary bypass,”J. Cardiovasic Surg., vol. 43(4), pp. 437-444.
Lin et al.; “Plasma and urine levels of urinary trypsin inhibitor in patients with acute and fulminant hepatitis,”Journal of Gastroenterology and Hepatology, vol. 17, pp. 140-147; 2002.
Pugia et al.; “Clinical utility of a rapid test for uristatin,”Clinical Biochemistry, vol. 32, pp. 105-110, 2002.
Moriyama et al.; “Expression of Inter-α Inhibitor Related Proteins in Kidneys and Urine of Hyperoxaluric Rats,”The Journal of Urology, vol. 165, pp. 1687-1692, May 2001.
Takubo et al.; “Urinary trypsin inhibitor levels in the urine of patients with haematological malignancies,”Haematologia, vol. 31 (3), pp. 267-272 (2001).
Suzuki et al.; “Excretion of Bikunin and Its Fragments in the Urine of Patients with Renal Stones,”The Journal of Urology, vol. 166, pp. 268-274, Jul. 2001.
Janssen et al.; “Expression of inter-α-trypsin inhibitor and tumor necrosis factor-stimulated gene 6 in renal proximal tubular epithelial cells,”Kidney International, vol. 60, pp. 126-136, 2001.
Mizon et al.; “The chondroitin sulfate chain of bikunin-containing proteins in the inter-α-inhibitor family increases in size in inflammatory diseases,”Eur. J. Biochem, vol. 268, pp. 2217-2724, 2001.
Suzuki et al.; “Structure and function analysis of urinary trypsin inhibitor (UTI): identification of binding domains and signaling property of UTI by analysis of truncated proteins,”Biochimica et Biophysica Acta, pp. 26-36, 2001.
Kobayashi et al.; “Identity of Urinary Trypsin Inhibitor-binding Protein to Link Protein,”The Journal of Biological Chemistry, vol. 275 (28), pp. 21185-21191, Jul. 14, 2000.
Thuveson et al.; “The Low pH in Trans-Golgi Triggers Autocatalytic Cleavage of Pre-α-inhibitor Heavy Chain Precursor,”The Journal of Biological Chemistry, vol. 275 (40), pp. 30996-31000, Oct. 6, 2000.
Mizon et al.; “Human pre-α-inhibitor is a positive acute-phase protein that is more susceptible than inter-α-inhibitor to proteolysis by stimulated neutrophils,”European Journal of Clinical Investigation, vol. 30, pp. 79-86, 2000.
Dean et al.; “Effects of inter-α-inhibitor and several of its derivatives on calcium oxalate crystallization in vitro,”Clinical Science, vol. 98, pp. 471-480, 2000.
Balduyck et al.; “Inflammation-induced systemic proteolysis of inter-α-inhibitor in plasma from patients with sepsis,”J. Lab Clin Med, vol. 135 (2), pp. 188-198, Feb. 2000.
Fries et al.; “Bikunin—not just a plasma proteinase inhibitor,”The International Journal of Biochemistry&Cell Biology, vol. 32, pp. 125-137, 2000.
Iida et al.; “Expression of Bikunin mRNA in Renal Epithelial Cells After Oxalate Exposure,”The Journal of Urology, vol. 162, pp. 1480-1486, Oct. 1999.
Marengo et al.; “Differential Expression of Urinary Inter-α-Trypsin Inhibitor Trimers and Dimers in Normal Compared to Active Calcium Oxalate Stone Forming Men,”The Journal of Urology, vol. 159, pp. 1444-1450, May 1998.
Bost et al.; “Intera-α-trypsin inhibitor proteoglycan family, A group of proteins binding and stabilizing the extracellular matrix,”Eur. J. Biochem, vol. 252, pp. 339-346, 1998.
Dawson et al.; “Inter-α-inhibitor in calcium stones,”Clinical Science, vol. 95, pp. 187-193, 1998.
Mizon et al.; “Human pre-a-inhibitor: isolation from a by-product of industrial scale plasma fractionation and structural analysis of its H3 heavy chain,”Journal of Chromatography B, vol. 692, pp. 281-291, 1997.
Marlor et al.; “Identification and Cloning o
Anderson-Mauser Linda
Gleason Shannon
Murphy Solomon H.
Pugia Michael J.
Sommer Ronald G.
Gambel Phillip
Pollack, Esq. Noam R.
Siemens Healthcare Diagnostics Inc.
Wells, Esq. Harold
Wen Sharon
LandOfFree
Monoclonal antibodies for detection of urinary trypsin... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Monoclonal antibodies for detection of urinary trypsin..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Monoclonal antibodies for detection of urinary trypsin... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3928795