Monoclonal antibodies for detecting Norwalk virus

Details Monoclonal antibodies for detecting Norwalk virus Monoclonal antibodies for detecting Norwalk virus

1996-08-15

1999-01-19

Woodward, Michael P.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

5303871, 5303872, 5303881, C12Q 170, C07K 1600

Patent

active

058612416

ABSTRACT:
Monoclonal antibodies and their use in assays to determine the presence of Norwalk virus, Norwalk virus particles, or Norwalk virus-specific IgM, in a biological sample. One assay includes the steps of contacting the sample with a monoclonal antibody that specifically binds to Norwalk virus particles in human stool; reacting the sample and the antibody for a time and under conditions that allow the formation of an immunocomplex between the antibody and any Norwalk virus in the sample; and detecting the immunocomplex, the presence of the immunocomplex indicating the presence of human Norwalk virus in the sample. Another assay is an IgM capture antibody immunoassay.

REFERENCES:
patent: 5559014 (1996-09-01), Estes et al.
Graham et al., "Norwalk Virus . . . in Improved Assays", The Journal of Infectious Diseases, 170:34-43, (1994).
Green et al., "Comparison of the Reactivities . . . Epidemiologic Observations", Journal of Clinical Microbiology, 31:2185-2191, (1993).
Herrmann et al., "Monoclonal Antibodies . . . Antigen in Stools", Journal of Clinical Microbiology, 33:2155-2513, (1995).
Jiang et al., "Expression, Self-Assembly . . . Capsid Protein", Journal of Virology, 66:6527-6532, (1992).
Okhuysen et al., "Viral Shedding and Fecal . . . Norwalk Virus Infection", The Journal of Infectious Diseases, 171:566-569, (1995).

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