Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,...
Patent
1995-05-23
1998-02-24
Scheiner, Toni R.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
4241981, 4241781, 4241381, 424 851, 4241561, 4241431, 5303877, 53038885, 5303913, 5303917, A61K 3900, C07K 1630, C12P 2108
Patent
active
057209545
ABSTRACT:
A method of inhibiting growth of tumor cells which overexpress a growth factor receptor or growth factor by treatment of the cells with antibodies which inhibit the growth factor receptor function, is disclosed. A method of treating tumor cells with antibodies which inhibit growth factor receptor function, and with cytotoxic factor(s) such as tumor necrosis factor, is also disclosed. By inhibiting growth factor receptor functions tumor cells are rendered more susceptible to cytotoxic factors.
REFERENCES:
patent: 4699877 (1987-10-01), Cline et al.
patent: 4753894 (1988-06-01), Frankel et al.
patent: 4909606 (1990-03-01), Honn et al.
patent: 4957735 (1990-09-01), Huang
patent: 4968603 (1990-11-01), Slamon et al.
patent: 5108934 (1992-04-01), Rokugawa et al.
patent: 5288477 (1994-02-01), Bacus
patent: 5401638 (1995-03-01), Carney et al.
Pennica et al Nature 312:724-729, (1984).
Drebin et al PNAS 83:9129-9133 (1986).
Masui et al Cancer Research 46:5592-5598 (1986).
Bellet et al J Natl. Can. Inst. 63:1185-1188 (1979).
Akiyama et al., "Potentation of Cytotoxic Activity of Immunotoxins on Cultured Human Cells" Cancer Research 45:1005-1007 (1985).
Akiyama et al., "The product of the human c-erbB-2 Gene: a 185-Kilodalton Glycoprotein with tyrosine Kinase Activity" Science 232:1644-1646 (1986).
Coussens et al., "Tyrosine Kinase Receptor with Extensive Homology to EGF Receptor Shares Chromosomal Location with neu Oncogene" Science 230:1132-1139 (1985).
Douillard et al., "Radioimmunotection of Human Tumors with Radiolabeled Monoclonal Antibodies" Oncogenes to Tumor Antigens, Geraldo et al. (eds.), Elsevier Sci. Publ. (1985).
Drebin et al., "Development of Monoclonal Antibodies Reactive with the Product of the neu Oncogene" Symposium on Fundamental Cancer Research 38:277-289 (1986).
Drebin et al., "Down-Modulation of an Oncogene Protein Product an Reversion of the Transformed Phenotype by Monoclonal Antobodies" Cell 41(3):695-706 (1985).
Drebin et al., "Inhibition of tumor growth by a monoclonal antibody reactive with an oncogene-encoded tumor antigen" Proc. Natl. Acad. Sci. 83:9129-9133 (1986).
Drebin et al., "Monoclonal antibodies identify a cell-surface antigen associated with an activated cellular oncogene" Nature 312:545-548 (1984).
Fendly et al., "Characterization of murine monoclonal antibodies reactive to either the human epidermal growth factor receptor or HER2
eu gene product" Cancer Research 50:1550-1558 (1990).
Fukushige et al., "Localization of a Novel v-erbB-Related Gene, c-erbB-2, on Human Chromosomes 17 and its Amplification in a Gastric Cancer Cell Line" Molecular & Cellular Biology 6(3):955-58 (1986).
Gill et al., "Monoclonal Anti-epidermal Growth Factor Receptor Antibodies Which are Inhibitors of Epidermal Growth Factor Binding and Antagonists of Epidermal Growth Factor-stimulated Tyrosine Kinase Activity" Journal of Biological Chemistry 259:7755-60 (1984).
Hudziak et al., "Increased expression of the putative growth factor receptor p185.sup.HER2 causes transformation and tumorigenesis of NIH 3T3 cells" Proc. Natl. Acad. Sci. 84:7159-7163 (1987).
Hudziak et al., "p185.sup.HER2 Monoclonal Antibody Has Antiproliferative Effects In Vitro and Sensitizes Human Breast Tumor Cells to Tumor Necrosis Factor" Molecular & Cellular Biology 9(3):1165-1172 (1989).
King et al., "Amplification of a Novel v-erbB-Related Gene in a Human Mammary Carcinoma" Science 229:974-976 (1985).
Kipps et al., "Schemata for the production of monoclonal antibody-producing hybridomas" Handbook of Experimental Immunology, Herzenberg et al. (eds.), Blackwell Sci., Chapter 108, pps. 108.1-108.9 (1986).
Lupu et al., "Direct interaction of a ligand for the erbB2 oncogene product with the EGF receptor and p185.sup.erbB2 " Science 249:1552-1555 (1990).
Mansui et al., "In vivo Evaluation of an Anti-Melanoma Antibody, F(ab')2, Labelled with TC-99m" Oncogenes to Tumor Antigens, Geraldo et al., eds., Elsevier Sci. Publ. (1985).
Masui et al., "Mechanism of Antitumor Activity in Mice for Anti-Epidermal Growth Factor Receptor Monoclonal Antibodies with Different Isotypes" Cancer Research 46:5592-5598 (1986).
McKenzie et al., "Generation and characterization of monoclonal antibodies specific for the human neu oncogene product, p185" Oncogene 4:543-548 (1989).
Morrison, "Transfectomas Provide Novel Chimeric Antibodies" Science 229:1202-1207 (1985).
Muller et al., "Single-Step Induction of Mammary Adenocarcinoma in Transgenic Mice Bearing the Activated c-neu Oncogene" Cell 54:105-115 (1988).
Myers et al., "Biological Effects of Monoclonal Antireceptor Antibodies Reactive with neu Oncogene Product, p185.sup.neu " Methods in Enzymology 198:277-290 (1991).
Padhy et al., "Identification of a Phosphoprotein Specifically Induced by the Transforming DNA of Rat Neuroblastomas" Cell 28:865-871 (1982).
Rodeck et al., "Interactions between growth factor receptors and corresponding monoclonal antibodies in human tumors" J. Cellular Biochem. 35(4):315-320 (1987).
Rodeck et al., "Tumor Growth Modulation by a Monoclonal Antibody to the Epidermal Growth Factor Receptor: Immunologically Mediated and Effector Cell-independent Effects" Cancer Research 47(14):3692-3696 (1987).
Rosenthal et al., "Expression in Rat Fibroblasts of a Human Transforming Growth Factor-.alpha. cDNA Results in Transformation" Cell 46:301-309 (1986).
Sato et al., "Biological Effects in Vitro of Monoclonal Antibodies to Human Epidermal Growth Factor Receptors" Mol. Biol. Med. 1:511-529 (1983).
Schechter et al., "The neu Gene: An erbB-Homologous Gene Distinct from and Unlinked to the Gene Encoding the EGF Receptor" Science 229:976-978 (1985).
Schlom et al., "Basic Principles and Applications of Monoclonal Antibodies on the Management of Carcinomas: The Richard and Hinda Rosenthal Foundation Award Lecture" Cancer Research 46:3225-3238 (1986).
Semba et al., "A v-erbB-related protooncogene c-erbB-2, is distinct from the c-erb-B-1/epidermal growth factor-receptor gene and is amplified in a human salivary gland adenocarcinoma" Proc. Natl. Acad. Sci. USA 82:6497-6501 (1985).
Slamon et al., "Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2
eu Oncogene" Science 235:177-182 (1987).
Sobol et al., "Epidermal Growth Factor Receptor Expression in Human Lung Carcinomas Defined by a Monoclonal Antibody" J, Natl. Cancer Institute 79(3):403-407 (1987).
Sugarman et al., "Effects of Growth Factors on the Antiproliferative Activity of Tumor Necrosis Factor" Cancer Research 47:780-786 (1987).
Sugarman et al., "Recombinant Human Tumor Necrosis Factor-.alpha.: Effects on Proliferation of Normal and Transformed Cells in Vitro" Science 230:943-945 (1985).
Takahashi et al., "Radioimmunodetection of Human Glioma Xenografts by Monoclonal Antibody to Epidermal Growth Factor Receptor" Cancer Research 47:3847-3850 (1987).
Urban et al., "Tumor necrosis factor: A potent effector molecule for tumor cell killing by activated macrophages" Proc. Natl, Acad. Sci. 83:5233-5237 (1986).
Van de Vijver et al., "Amplification of the neu (c-erbB-2) Oncogene in Human Mammary Tumors Is Relatively Frequent and Is Often Accompanied by Amplification of the Linked c-erbA Oncogene" Molecular & Cellular Biology 7(5):2019-2023 (1987).
Venter et al., "Overexpression of the c-erbB-2 Oncoprotein in Human Breast Carcinomas: Immunohistological Assessment Correlates with Gene Amplification" Lancet pps. 69-72 (1987).
Vitetta et al., "Redesigning nature's poisons to create anti-tumor reagents" Science 238:1098-1104 (1987).
Vollmar et al., "Toxicity of Ligand and Antibody-Directed Ricin A-Chain Conjugates Recognizing the Epidermal Growth Factor Receptor" J. Cellular Physiology 131:418-425 (1987).
Yamamoto et al., "Similarity of protein encoded by the human c-erb-B-2 gene to epidermal growth factor receptor" Nature 319:230-34 (1986).
Drebin et al., "Monoclonal Antibodies Specific for the neu Oncogene Product Directly Mediate Anti-tumor Effects In Vivo" Oncogene 2(4):387-394 (1988).
Hudziak et al., "Amplified Expression of the HER2/ERBB2 Oncogene Induces Resistance to Tumor Necrosis Factor
Fendly Brian M.
Hudziak Robert M.
Shepard H. Michael
Ullrich Axel
Bansal Geetha P.
Genentech Inc.
Lee Wendy M.
Scheiner Toni R.
LandOfFree
Monoclonal antibodies directed to the HER2 receptor does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Monoclonal antibodies directed to the HER2 receptor, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Monoclonal antibodies directed to the HER2 receptor will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1873510