Monoclonal antibodies directed to IL-1 activated endothelial cel

Details Monoclonal antibodies directed to IL-1 activated endothelial cel Monoclonal antibodies directed to IL-1 activated endothelial cel

1989-05-23

1991-04-30

Kepplinger, Esther L.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

530387, 424 858, 435 7021, 4351722, C12N 520, C07K 1528, A61K 3900

Patent

active

050117785

ABSTRACT:
Hybridoma cell lines are made that produce monoclonal antibodies having, among others, the following identifying characteristics: (1) bind to IL-1 activated endothelial cells; (2) do not bind significantly to normal resting endothelial cells; (3) do not bind significantly to normal resting or IL-1 activated epidermal keratinocytes or resting or IL-1 activated fibroblasts. The monoclonal antibodies are used in therapeutic compositions for blocking inflammatory responses associated with activated endothelial cells.

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