Monoclonal antibodies directed against the microtubule-associate

Details Monoclonal antibodies directed against the microtubule-associate Monoclonal antibodies directed against the microtubule-associate

1995-02-15

1999-01-19

Duffy, Patricia

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 721, 435 792, 435 795, 436518, 436 63, 436811, G01N 3353

Patent

active

058612572

ABSTRACT:
The invention relates to a monoclonal antibody which forms an immunological complex with an epitope of an antigen belonging to normal human tau protein as well as abnormally phosphorylated human tau protein, with said tau protein being liable to be obtained from a brain homogenate, itself isolated from human cerebral cortex. The monoclonal antibodies of the invention can be used to detect tau and abnormally phosphorylated tau in brain extracts and in unconcentrated cerebrospinal fluid.

REFERENCES:
patent: 5492812 (1996-02-01), Vooheis
Goedert et al, The EMBO Journal Article.vol. 8 pp. 393-399 1989.
Papasozomenos et al, Proc. Natl. Acad. Sci. USA Article vol. 88 May 1991 pp. 4543-4547 Biochemistry.
Yen et al, Am J. Pathol, 126:81-91, 1987.
Novak et al, Proc. Natl. Acad. Sci 88:5837-5841, 1991.
Mercken et al, Journal of Neurochemistry, 58:548-553, 1992.

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