Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1991-09-23
1994-03-22
Rosen, Sam
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 7021, 43524027, 435 79, 53038885, 5303893, A61K 3514, C07K 1500
Patent
active
052963527
ABSTRACT:
The invention concerns monoclonal antibodies which are directed against the thrombin/hirudin-complex and derivatives thereof, processes for their preparation, hybridoma cell lines secreting said monoclonal antibodies, and processes for the preparation of the hybridoma cell lines. Furthermore, the invention relates to the use of the monoclonal antibodies and/or their derivatives for the determination of the thrombin/hirudin-complex as well as to test kits comprising said monoclonal antibodies and/or their derivatives.
REFERENCES:
Dawes et al-Chem. Abst. vol. 102 (1985) p. 76950e.
Chuang et al-Chem. Abst. vol. 104 (1986) p. 10,448g.
Spinner et al-J. of Immunol. Methods-vol. 87 (1986) pp. 79-83.
Suzuku et al., J. of Biol. Chem., 265:13263-13267 (1990).
Schlaeppi et al., Eur. J. Biochem., 188:463-470 (1990).
Ciba-Geigy Corporation
Rosen Sam
Spruill W. Murray
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