Monoclonal antibodies capable of recognizing gangliosides GQ.sub

Details Monoclonal antibodies capable of recognizing gangliosides GQ.sub Monoclonal antibodies capable of recognizing gangliosides GQ.sub

1989-07-10

1992-08-25

Doll, John J.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

5303882, 43524027, 4351722, C07K 1528, C12N 518, C12N 1502

Patent

active

051420287

ABSTRACT:
A monoclonal antibody specifically recognizes an epitope or an antigenic determinant represented by the following formula and specifically reacts therewith: ##STR1## The monoclonal antibody can be obtained by cultivating hybridoma cells which can be generated by a method comprising cell-fusing (A) B cells or lymphocytes obtained by immunizing an animal with a substance involving the epitope or the antigenic determinant represented by the foregoing formula and (B) myeloma cells. The monoclonal antibody shows high specificity to ganglioside GQ.sub.1b and ganglioside GT.sub.1a having a specific epitope and thus can detect the epitope in high sensitivity. Therefore, the antibody can be used for the elucidation of sugar chain's roles in cell functions and for studying the development of animals. Moreover, the monoclonal antibody would have various clinical applications.

REFERENCES:
Kasai et al., Brain Res., 277:155-158, 1983.
Biological Abstracts, vol. 77, No. 10, 1984, abstract No. 77313, Philadelphia, Pa., US; S. K. Kundu et al.: "Binding of Monoclonal Antibody A2B5 to Gangliosides".
Biochem. Biophys. Res. Commun. 116(3), 836-842, 1983.
J. Exp. Med. The Rockefeller University Press, vol. 150, Oct. 1979, 1008-1019.
Eur. J. Immunol. 1986, 16: 951-956, Thomas Brodin et al.

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