Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Cancer cell or component thereof
Patent
1995-03-08
1997-08-26
Cunningham, Thomas M.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Cancer cell or component thereof
4241841, 4241931, 514 8, 514 23, 530395, A61K 3814, A61K 3900, A61K 3939, C07K 1482
Patent
active
056608349
ABSTRACT:
A vaccine and method to prevent growth and replication of cancer cells that express a core structure of a mucin-type glycoprotein is disclosed. The vaccine comprises: (a) a pharmaceutically effective amount of an antigen comprising a purified mucin-type glycoprotein or a chemically synthesized mucin-type glycoprotein carbohydrate determinant conjugated to a carrier peptide or macromolecule, wherein said mucin-type glycoprotein expresses or carries the core structure of a mucin-type glycoprotein expressed on said cancer cells; and (b) a pharmaceutically acceptable carrier including natural or synthetic adjuvants. The method comprises administering the above-described vaccine to a host. A medicament and method for treating cancer wherein the cancer cells express a core structure of a mucin-type glycoprotein is disclosed. The medicament comprises: (a) a pharmaceutically effective amount of an anti-cancer antibody or fragment comprising a binding site thereof, said anti-cancer antibody having been produced against a purified core structure of a mucin-type glycoprotein; and (b) a pharmaceutically acceptable carrier, diluent or excipient. The method comprises administering the above-described medicament to a host.
REFERENCES:
Basic and Clinical Immunology (1980), pp. 304-312.
Hakomori, S., Ann. Rev. Immunol 2:103-126 (1984), "Tumor-associated carbohydrate antigens".
Lan, M. S., et al. J. Biol. Chem 262:12863-12870 (1987), "Molecular Characterization of a mucin-type antigen associated with a human pancreatic cancer."
Magnani, J. L., et al. Cancer Res. 43:5489-92 (1983), "Identification of the gastrointestinal and pancreatic cancer-associated antigen detected by MAb 19-9 in the sera of patients as a mucin."
Sharon, N. et al. Scientific American, Jan. 1993. pp. 82-89. "Carbohydrates in cell recognition."
Boon, T. Sci. Am. Mar. 1993. pp. 82-89. Teaching the Immune system to fight cancer.
Clausen Henrik
Hakomori Sen-itiroh
Kjeldsen Thomas J.
Singhal Anil
Takahashi Helio K.
Cunningham Thomas M.
The Biomembrane Institute
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