Monoclonal antibodies and their use

Details Monoclonal antibodies and their use Monoclonal antibodies and their use

2011-07-19

2011-07-19

Rawlings, Stephen L (Department: 1643)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

C530S387100, C530S387300, C530S388200, C530S391300, C530S391700, C435S320100, C435S325000, C435S326000, C435S332000, C536S023500, C424S152100

Reexamination Certificate

active

07981628

ABSTRACT:
Isolated monoclonal antibodies are disclosed herein that specifically bind a cell surface antigen expressed on the human pancreatic endocrine cells or a subset thereof, and/or a precursor thereof. Isolated monoclonal antibodies are also disclosed herein that specifically bind a cell surface antigen expressed on human pancreatic exocrine cells or human ductal cells. Humanized forms of these antibodies, and functional fragments of these antibodies, are also disclosed. The antibodies can be conjugated to an effector molecule, such as a detectable marker, a therapeutic agent, or a toxin. These antibodies are of use to detect and isolate pancreatic cells or a subset thereof. The antibodies can be used for in vitro or in vivo detection and/or isolation of pancreatic endocrine cells. Methods of treating a pancreatic tumor are also disclosed. In several examples, the isolated monoclonal antibodies bind pancreatic endocrine cells and can be used to detect diabetes or a pancreatic endocrine cell tumor.

REFERENCES:
patent: 1 090 927 (2001-04-01), None
patent: WO 03/000021 (2003-01-01), None
patent: WO 2005/033126 (2005-04-01), None
Dorrell et al. (Stem Cell Res. Sep. 2008; 1 (3):183-194).
Gaisano et al., “SNAP-23 is located in the basolateral plasma membrane of a rat pancreatic acinar cells,”FEBS Letters, 414(2):298-302, (Sep. 8, 1997).
Gmyr et al., “Rapid purification of human ductal cells from human pancreatic fractions with surface antibody CA19-9,”Biochemical and Biophysical Research Communications, 300(1):27-33, (Jul. 16, 2004).
Kobayashi et al., (Expression of glucose transporter 4 in the human pancreatic islet of Langerhans,Biochemical and Biophysical Research Communications, 314(4):1121-1125, (Feb. 20, 2004).
Palumbo et al., “Human aspartyl (asparaginyl) beta-hydroxylase monoclonal pancreatic carcinoma,”Pancreas, 25(1):39-44, (Jul. 1, 2002).

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