Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1994-02-22
1995-11-21
Scheiner, Toni R.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
43524027, 435 721, 436548, G01N 3353, C12N 520, A61K 3514
Patent
active
054688469
ABSTRACT:
The present invention relates to a high affinity monoclonal antibody and to an enzyme immunoassay of human G-CSF using the antibody.
The trace amount of human G-CSF in samples such as body fluids from patients with hematological disorders can be measured without interference in the body fluids. For example, the measurable human G-CSF concentration in plasma is 0.5 pg/ml in minimum.
REFERENCES:
patent: 5164299 (1992-11-01), Lambert
Kiriyama, R. et al., Japanese Journal of Clinical Hematology, 33(10):1544 (1992).
Kurotani, W. et al., Japanese Journal of Clinical Hematology, 34(10):1307 (1993).
Motojima, H. et al., "Quantitative enzyme immunoassay for human granulocyte colony stimulating factor (G-CSF)", Journal of Immunological Methods, 118:187-192 (1989).
Omori, F. et al., "Measurement of Human G-CSF by Enzyme-linked Immunoabsorbent Assay Using Monoclonal Antobody", Research in Experimental Medicine, 189:163-171 (1989).
Omori, F. et al., "Levels of human serum granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor under pathological conditions", Biotherapy, 4:147-153 (1992).
Tachibana, K. et al., International Journal of Hematology, 55(1):202 (1992).
Watari, K. et al., "Serum Granulocyte Colony-Stimulating Factor Levels in Healty Volunteers and Patients with Various Disorders as Estimated by Enzyme Immunoassay", Blood, 73:117-122 (1989).
Hellstrom, K. E. et al. in Monoclonal Antibodies for Cancer Detection and Therapy, Baldwin et al., eds., Orlando, Fla.: Academic Press, 1985.
Sevier, E. D., et al. Monoclonal Antibodies in Clinical Immunology. Clinical Chemistry 27(11):1797-1806, 1981.
Shimamura, K. et al. Establishment of Specific Monoclonal Antibodies Against Recombinant human Granulocyte Colony Stimulating factor . . . Journal of Histochemistry & Cytochemistry 36(2) 283-286, 1990.
Ichikawa Takanori
Kuwaki Tomoaki
Matsuki Shigeru
Tachibana Katsumi
Kirin-Amgen Inc.
Parsons Nancy J.
Scheiner Toni R.
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