Monoclonal antibodies and method for identifying different aids-

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage

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435974, 435 72, 435 792, 435 793, 435 795, 435975, 43524027, 53038835, 5303871, C12Q 170, C12N 500, A61K 3514, C07K 300

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052544575

ABSTRACT:
Novel hybridoma cell lines and monoclonal antibodies are provided which can differentiate between HIV-1, HIV-2 and SIV retrovirus isolates. A synthetic peptide which is useful as a universal diagnostic reagent for detecting retroviral infection is also described.

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Guyder et al, "Genome organization and transactivation of the human immunodeficiency virus type 2," Nature 326 (1987) 662-669.
Chakrabarti et al, "Sequence of simian immunodeficiency virus from macaque and its relationship to other human and simian viruses", Nature 328 (1987) 543-547.
Niedrig et al, "Monoclonal Antibodies Directed Against Human Immunodeficiency Virus (HIV) gag Proteins with Specificity for conserved Epitopes in HIV-1, HIV-2 and Simian Immunodeficiency Virus" J. Gen. Virol. 69 (1988) 2109-2114.
Ratner et al, "Complete nucleotide sequence of the AIDS virus, HTLV-III" Nature, 313 (1985) 277-284.
Alizon et al, "Genetic Variability of the AIDS virus; Nucleotide Sequence Analysis of Two Isolates from African Patients," Cell 46 (1986) 63-74.

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