Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Bacteria or actinomycetales; media therefor
Patent
1995-05-31
1998-09-15
Feisee, Lila
Chemistry: molecular biology and microbiology
Micro-organism, per se ; compositions thereof; proces of...
Bacteria or actinomycetales; media therefor
4241341, 4241351, 4241921, 435 7021, 4351723, 4353201, 514 44, 5303873, 53038822, 536 2353, C07H 2104, C12N 1511, C12N 120, C12N 121
Patent
active
058077340
ABSTRACT:
An anti-CD2 monoclonal antibody according to the present invention can be: (1) a chimeric monoclonal antibody CD2 SFv-Ig produced by expression of the construct cloned in recombinant Escherichia coli culture ATCC No. 69277; (2) a monoclonal antibody having complementarity-determining regions identical with those of CD2 SFv-Ig; or (3) a monoclonal antibody competing with CD2 SFv-Ig for binding to CD2 antigen at least about 80% as effectively on a molar basis as CD2 SFv-Ig. Anti-CD2 monoclonal antibodies according to the present invention, as well as other antibodies that can modulate the interactions between T lymphocytes and monocytes, can be used to inhibit the production of HIV-1 by HIV-1-infected T cells in HIV-1-infected patients. In another use, T cells treated in vitro can be reinfused into AIDS patients to increase the proportion of functional, non-HIV-1-producing T cells in the patient.
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U. Hazan et al., "Stimu
Diegel Michael L.
Gilliland Lisa K.
Ledbetter Jeffrey A.
Linsley Peter S.
Moran Patricia A.
Bristol--Myers Squibb Company
Feisee Lila
Lucas John
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