Monoclonal antibodies and conjugates thereof useful for the trea

Details Monoclonal antibodies and conjugates thereof useful for the trea Monoclonal antibodies and conjugates thereof useful for the trea

1996-04-08

1998-10-06

Eisenschenk, Frank C.

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

4241811, 4241831, 424 149, 435332, 5303888, 5303897, 5303913, 5303917, A61K 39395, C07K 1630

Patent

active

058173137

ABSTRACT:
The invention provides a novel treatment of cancer using a monoclonal antibody that recognizes cell surface antigens present on a number of tumor cells, including ovarian, esophageal and cervical carcinomas. A preferred monoclonal antibody is secreted by a hybridoma deposited with the ATCC and has Accession NO. HB 10570.

REFERENCES:
Waldmann, Science, 252:1657, 1991.
Blattler, Cancer Cells, 1(2):50, 1989.
Riechmann et al., Nature, 332:323, 1988.
Abramowicz et al., New Engl. J. Med., Sep. 3, 1992, p. 736.
Blast et al., J. Clin. Invest., 68:1331, 1981.
Hamilton et al., Cancer Res., 43:5379, 1983.

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