Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2004-09-29
2008-10-14
Yu, Misook (Department: 1642)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C436S501000, C436S518000
Reexamination Certificate
active
07435554
ABSTRACT:
The invention provides new monoclonal antibodies and binding fragments thereof which recognize and immunoreact with cell surface antigens found on small cell lung cancer (SCLC) cells. The antibodies have tumor specificity and are useful for therapy, diagnosis, monitoring, detecting and imaging of SCLC disease and of patients having SCLC disease. The antibody-recognized SCLC-specific surface antigens can serve as targets for detecting, diagnosing, inhibiting or killing SCLC cells.
REFERENCES:
patent: 4585742 (1986-04-01), Bernal
patent: 5614373 (1997-03-01), Stahel
patent: 5665864 (1997-09-01), Quaranta et al.
patent: 6162616 (2000-12-01), Shyjan
Rosenbaum et al., PNAS, Dec. 1990;87(24):9928-32.
Voet et al., (1990, Biochemistry, John Wiley & Sons, p. 98, and 99 only).
B. Birk et al., “Cobas® Core CA 19-9 II EIA: New CA 19-9 Enzyme Immunoassay with High Correlation to Radioimmunoassays”, AntiCancer Research 17:2911-2914 (1997).
Y. Fujii et al., “Characterization of a murine monoclonal antibody, 5D-4, reacting with pancreatic cancers and islets of Langerhans”, Biomed & Pharmacother (1992) 46, 405-411.
J. Taylor et al., “Detection of Somatostatin Receptor Subtype 2 (SSTR2) in Established Tumors and Tumor Cell Lines: Evidence for SSTR2 Heterogeneity”, Peptides, vol. 15, No. 7, pp. 1229-1236 (1994).
Rose et al., “A novel antigen defined by monoclonal antibody CR101 is associated with small cell lung carcinoma” Hybridoma 13(3):221-227 (1994).
P. Krueger et al., “A new small cell lung cancer (SCLC)-specific marker discovered through antigenic subtraction of neuroblastoma cells”, Cancer Immunol Inmmunoother (2003) 52:367-377.
R. Freshney, “Culture of Animal Cells, A Manual of Basic Technique”, Alan R. Liss, Inc. 1983, New York, p. 4).
G. Dermer, “Another Anniversary for the War on Cancer”, Bio/Technology VO1. Mar. 12, 1994.
D. Voet et al. “Biochemistry”, John Wiley & Sons, p. 98 and 99 only.
J. Chin et al. “Reactivity of Monoclonal Anti-Human Pancreatic Carcinoma Antibodies AR2-20 and AR1-28 With Tumors of Nonpancreatic Origin”, American Journal of Pathology, vol. 126, No. 1 1987, pp. 183-193.
E. Ward, “Antibody Engineering, A Practical Guide”, W.H. Freeman and Company, Car. A.K. Borrebaeck, ed, pp. 122-123 only.
T. Soussi, 2000, “p53 Antibodies in the Sera of Patients with Various Types of Cancer: A Review”, Cancer Research, vol. 60 (7):1777-1788.
A.O. Güre et al., 2000, “Serological identification of embryonic neural proteins as highly immunogenic tumor antigens in small cell lung cancer”, PNAS, USA, vol. 97 (8):3783-4410.
S. Zöchbauer-Müller et al., 2002, “Molecular Pathogenesis of Lung Cancer”, Annual Review of Physiology, 64:681-708.
F.P. Worden et al., 2000, “Therapeutic advances in small cell lung cancer”, Exp. Opin. Invest. Drugs 9 (3):565-579.
Pettijohn, D. E. et al., “Glycoproteins Distinguishing Non-Small Cell from Small Cell Human Lung Carcinoma Recognized by Monoclonal Antibody 43-9F,”Cancer Research, 47:1161-1169, Feb. 15, 1987.
Waibel, R. et al., “Monoclonal antibodies defining the cluster-5A small cell lung carcinoma antigen,”Br. J. Cancer, 63(S. XIV):29-32, 1991.
Zarn, J. A. et al., “Association of CD24 with the Kinase c-fgr in a Small Cell Lung Cancer Cell Line and with the Kinase lyn in an Erythroleukemia Cell Line,”Biochemical and Biophysical Research Communications, 225(2):384-391, Article No. 1184, Aug. 14, 1996.
ImmunoCellular Therapeutics, Ltd.
Morgan & Finnegan , LLP
Yu Misook
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