Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1985-12-13
1989-09-05
Moskowitz, Margaret
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
530388, 530389, 530399, 530808, 530809, 435 68, 4351722, 4352401, 43524027, 935 89, 935 95, 424 11, 424 858, C07K 1500, C12N 1500
Patent
active
048640204
ABSTRACT:
Monoclonal antibodies specific for an antigen present on the surface of parathyroid tissue are useful in imaging such tissue when conjugated to suitable label. The antibodies of the invention bind exclusively to parathyroid surfaces and do not bind to other tissues. The antibodies are useful in establishing the location of the parathyroid whether in its normal location or in ectopic placements. An exemplary monoclonal has been deposited at the American Type Culture Collection and has accession number ATCC No. HB9917.
REFERENCES:
Posillico et al., J. Clin. Endocrin. Met. 64(1) 1987, p. 43.
Srikanta et al., Endocrinology 126(6) 1987, p. 2240.
Posillico et al., (1985) Clin. Res. 33:573A.
Srikanta et al., (1987) Endocrinology 120:2240-2244.
Posillico et al., (1987) J Clin Endocrinol Metab 64:43-50.
Nussbaum et al., Methods of Enzymol., 1985, vol. 109, pp. 625-638.
Nussbaum et al., CA vol. 105, 1986 #151143m.
Weinshank, et al., CA vol. 103, 1985, #190337f.
Cance William G.
Davie Joseph M.
Dilley William G.
Morrissey, IV Jeremiah J.
Welch Michael J.
Draper Garnette D.
Moskowitz Margaret
Washington University School of Medicine
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