Monoclonal antibodies agaisnt GnRH

Details Monoclonal antibodies agaisnt GnRH Monoclonal antibodies agaisnt GnRH

1987-05-15

1989-11-07

Tarcza, John E.

Drug, bio-affecting and body treating compositions

Lymphokine

530387, 435 68, 43524027, 4351722, 935104, 935107, A61K 39395, C12N 500, C12N 1500, C12P 2100

Patent

active

048791121

ABSTRACT:
A monoclonal antibody against GnRH and particularly designated USASK/DSIL-GnRH is produced by a hybrid formed by fusion of cells from a myeloma line and antibody producing cells of the immune system from an animal previously immunized with a source of GnRH; the monoclonal antibody has the following characteristics:

REFERENCES:
patent: 4676981 (1987-06-01), Silversides et al.
Talwar et al, 2nd Int. Conference on Immunopharmacology ed, Hadden et al, Jun. 1983, pp. 415-420.
Arimura, A., L. Debeljuk, and A. V. Schally, Endocrinology 95: 323, 1974.
McCormack et al, Endocrinology, 100(3), pp. 633-667 (1977).
Shastri et al, Am. J. Reprod. Immunol. 1, pp. 262-265 (1981).
Siddle et al, Monoclonal Antibodies and Developments in Immunoassay, ed. Albertini (1981), pp. 53-66.
Lincoln et al, J. Reprod. Fert. 66, pp. 703-708 (1982).
Koch, Y. P. Chobsieng, U. Zor, M. Fridkin, and H. R. Lindner, Biochem Biophys Res. Commun 55: 623, 1973.
Kerdelhue, B., S. Catin, and M. Jutisz, In Motta, M., P. G. Crosignani, and L. Martini (eds.), Hypothalmic Hormones, Academic Press, London, 1975, p. 49.

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