Monoclonal antibodies against type I phospholipase A.sub.2 as a

Details Monoclonal antibodies against type I phospholipase A.sub.2 as a Monoclonal antibodies against type I phospholipase A.sub.2 as a

1995-08-08

1998-06-16

Scheiner, Toni R.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

53038825, 4241301, 4241401, C07K 1640, A61K 39395

Patent

active

057672490

ABSTRACT:
The invention provides for monoclonal antibodies which specifically bind to type I phospholipase A.sub.2 for use as a diagnostic agent and as an anti-inflammatory therapeutic agent, which is particularly suitable for application in acute pancreatitis. The invention further provides for pharmaceutical compositions including the antibodies of the invention. The invention also provides for a method for treating subjects suffering from inflammatory symptoms and for detecting the activity of type I phospholipase A.sub.2 in a sample.

REFERENCES:
patent: 5244789 (1993-09-01), Neumann et al.
Misaki et al., Production and Cahracterization of Monoclonal Antibodies against Human Pancreatic Phospholipase A2. J.Clin. Biochem. Nutr. vol. 11, pp. 79-89, 1991.
Waldmann, Monoclonal Antibodies in Diagnosis and Therapy, Science, vol. 252, 1657-1662, 1991.
Takamaya et al., "Monoclonal Antibodies Against Human Synovial Phospholipase A2", Biochemical and Biophysical Research Communications, vol. 167, No. 3, pp. 1309-1315 (1990).

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