Monoclonal antibodies against tumor-associated antigens, a proce

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

4353441, 435329, 5303875, 53038885, G01N 33574, C12N 520

Patent

active

056396228

ABSTRACT:
The invention relates to monoclonal antibodies (MAbs) and fragments thereof which bind to defined tumor-associated antigens, principally of small cell lung carcinoma (SCLC), of melanoma, of neuroblastoma and other tumors of neuroectodermal origin, to hybridoma cell lines for the preparation thereof, and to the antigens which can be defined and/or isolated with the aid of these antibodies or antibody fragments. The antibodies, antibody fragments and antigens can be used as diagnostic. aid, active substance or active substance carrier.

REFERENCES:
patent: 4503143 (1985-03-01), Gerber et al.
patent: 5284931 (1994-02-01), Springer et al.
Schol et al., "MAb 123C3 identifying SCLC phenotype in lung tumors, recognizes mainly, but not exclusively, endocrine and neuron-supporting normal tissues," Int. J. Cancer 2(Supp):34-40 (1988).
DeLey, et al. "Neuroendocrine and epithelial antigens in SCLC," Lung Cancer, 4:42-44 (1988).
Udea et al., "Serological and Biochemical Analysis of four antigens associated with SCLC," Lung Cancer, 4:96-98. (1988).
Hirohashi et al., "145KDa cell membrane Ag on SCLCs as a common target for several MAb raised against SCLCs," Lung Cancer, 4:103-104. (1988).
Rosier et al., "Flow cytometry analysis of the reactivity on human blood leucocytes of a group of Mab reacting with SCLC and neural tissues," Lung Cancer, 4:58-61. (1988).
Roitt, Encyclopedia of Immunology, 1992, Academic Press, London, U.K., pp. 1444-1445.
S. Pahlman et al., "Purification and Characterization of Human Neuron-Specific Enolase: Radioimmunoassay Development," Tumour Biology, 5:127-139 (1984).
A. Maier et al., "Expression of the Small Cell Carcinoma Antigens of Cluster-5 and Cluster 5-A in Primary Lung Tumours," Br. J. Cancer, 59:692-695 (1989).
R.L. Souhami et al., "The First International Workshop on Small Cell Lung Cancer Antigens," Lung Cancer, 4:1-4 (1988).
K. Patel et al., "Neural Cell Adhesion Molecule (NCAM) is the Antigen Recognized by Monoclonal Antibodies of Similar Specific in Small-Cell Lung Carcinoma and Neuroblastoma," Int. J. Cancer, 44:573-578 (1989).
K. Patel et al., "Monoclonal Antibody UJ13A Recognizes the Neural Cell Adhesion Molecule (NCAM)," Int. J. Cancer, 44:1062-1068 (1989).
J. Finne et al., "An IgG Monoclonal Antibody to Group B Memingococci Cross-Reacts with Developmentally Regulated Polysialic Acid Units of Glycoproteins in Neural and Extraneural Tissues," The Journal of Immunology, 0022-1767:4402-4407 (1987).
J. Hayrinen et al., "Interaction of Meningococcal Group B Monoclonal Antibody and its Fab Fragment with .alpha.2-8-Linked Sialic Acid Polymers: Requirement of a Long Oligosaccharide Segment for Binding," Molecular Immunology, 26:523-529 (1989).
P.T. Jones et al., "Replacing the Complementarity-Determining Regions in a Human Antibody With Those From a Mouse," Nature, 321:522-525 (1986).
M. Verhoeyen et al., "Reshaping Human Antibodies: Grafting an Antilysozyme Activity," Science, 239:1534-1536 (1988).
M. Shulman et al., "A Better Cell Line for Making Hybridomas Secreting Specific Antibodies," Science, 276:269-270 (1978).
G. Kohler et al., "Continuous Cultures of Fused Cells Secreting Antibody of Predefined specificity," Nature, 256:495-497 (1975).
J.L. Cordell et al., "Immunoenzymatic Labeling of Monoclonal Antibodies Using Immune Complexes of Alkaline Phosphatase and Monoclonal Anti-alkaline Phosphatase (APAAP Complexes), " The Journal of Histochemistry and Cytochemistry, 32:219-229 (1984).
P.L. Ey et al., "Isolation of Pure IgG.sub.1, IgG.sub.2b Immunoglobulins From Mouse Serum Using Protein A-Sepharose," Immunochemistry, 15:429-436 (1978).
R.E. Kibbelaar et al., "Expression of the Embryonal Neural Cell Adhesion Molecule N-Cam in Lung Carcinoma. Diagnostic Usefulness of Monoclonal Antibody 735 for the Distinction Between Small Cell Lung Cancer and Non-Small Cell Lung Cancer," Journal of Pathology, J. Finne et al., 159:23-28 (1989).
C.E.C.K. Moolenaar et al., "Expression Of Neural Cell Adhesion Molecule-related Sialoglycoprotein In Small Cell Lung Cancer and Neuroblastoma Cell Lines H69 And CHP-212," Cancer Research, 50:1102-1106 (Feb. 15, 1990).
B.B. Fuchs et al., "Biochemical and Immunochemical Analysis of Ganglio-sides of Human Cell Small Lung Carcinoma: Production of Monoclonal Antibodies Against A Unique Marker Of Small Cell Lung Carcinoma, Ganglioside Fuc GM.sub.1," Biotechnology and Applied Biochemistry, 10:273-286 (1988).
J. Watanabe et al., "Monoclonal Antibody That Distinguishes Small-Cell Lung Cancer From Non-Small-Cell Lung Cancer," Cancer Research, 47:826-829 (Feb. 1, 1987).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Monoclonal antibodies against tumor-associated antigens, a proce does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Monoclonal antibodies against tumor-associated antigens, a proce, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Monoclonal antibodies against tumor-associated antigens, a proce will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2157081

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.